TY - JOUR
T1 - Bone loss in adults receiving alternate day glucocorticoid therapy
AU - Gluck, Oscar S.
AU - Murphy, William A.
AU - Hahn, Theodore J.
AU - Hahn, Bevra
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1981/7
Y1 - 1981/7
N2 - Bone mineral content was measured by photon absorption densitometry in 25 patients with rheumatic diseases receiving glucocorticoids on an alternate day treatment schedule, and in 25 age‐, sex‐, and race‐matched patients receiving daily steroid therapy. Mean values for cortical (diaphyseal) mass, trabecular (metaphyseal) mass, and the cortical/trabecular mass ratios were not different in the two groups. Steroid‐induced osteopenia, defined as an elevated ratio of cortical to trabecular mass, occurred in both therapeutic regimens (8 of 25 on alternate day; 11 of 25 on daily). Therefore, bone loss was demonstrable in individuals on alternate day regimens. Serum levels of calcium, ionized calcium, alkaline phosphatase, and parathyroid hormone were similar in the two groups.
AB - Bone mineral content was measured by photon absorption densitometry in 25 patients with rheumatic diseases receiving glucocorticoids on an alternate day treatment schedule, and in 25 age‐, sex‐, and race‐matched patients receiving daily steroid therapy. Mean values for cortical (diaphyseal) mass, trabecular (metaphyseal) mass, and the cortical/trabecular mass ratios were not different in the two groups. Steroid‐induced osteopenia, defined as an elevated ratio of cortical to trabecular mass, occurred in both therapeutic regimens (8 of 25 on alternate day; 11 of 25 on daily). Therefore, bone loss was demonstrable in individuals on alternate day regimens. Serum levels of calcium, ionized calcium, alkaline phosphatase, and parathyroid hormone were similar in the two groups.
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U2 - 10.1002/art.1780240705
DO - 10.1002/art.1780240705
M3 - Article
C2 - 7259801
AN - SCOPUS:0019413390
SN - 0004-3591
VL - 24
SP - 892
EP - 898
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 7
ER -