TY - JOUR
T1 - Bone marrow stem-cell therapy for genetic and chronic liver diseases
AU - Kochat, Veena
AU - Baligar, Prakash
AU - Maiwall, Rakhi
AU - Mukhopadhyay, Asok
N1 - Funding Information:
Acknowledgements The last author is grateful to the Department of Biotechnology, Government of India, for funding of The Centre for Molecular Medicine, National Institute of Immunology.
PY - 2014/4
Y1 - 2014/4
N2 - There are no permanent remedies for patients suffering from genetic liver diseases (GLDs) and liver cirrhosis (LC). In such cases, liver transplantation has resulted in improved quality of life, but it is not affordable by most patients. Therefore, a cost-effective, safe, and permanent cure for these diseases is desirable. Cell therapy seems an encouraging option for treatment of these liver diseases in the future. Animal experiments and clinical studies have demonstrated that, depending on the nature of the liver disease and the patient, autologous and/or allogeneic bone marrow (BM)-derived stem-cell therapy could be a promising treatment option. Although no clinical trials using BM-derived stem cells for treatment of GLD have yet been conducted, many phase I clinical trials have been conducted and a few such trials for the treatment of LC by use of autologous and/or allogeneic cells are in progress. Overall, the results of these trials are indicative of clinical benefits with no adverse effect on the patients. This review focuses on the current status of BM stem-cell therapy for treatment of GLD and LC in experimental animals and human subjects. It also proposes safer approaches to immune-regulation in allogeneic transplantation of cells.
AB - There are no permanent remedies for patients suffering from genetic liver diseases (GLDs) and liver cirrhosis (LC). In such cases, liver transplantation has resulted in improved quality of life, but it is not affordable by most patients. Therefore, a cost-effective, safe, and permanent cure for these diseases is desirable. Cell therapy seems an encouraging option for treatment of these liver diseases in the future. Animal experiments and clinical studies have demonstrated that, depending on the nature of the liver disease and the patient, autologous and/or allogeneic bone marrow (BM)-derived stem-cell therapy could be a promising treatment option. Although no clinical trials using BM-derived stem cells for treatment of GLD have yet been conducted, many phase I clinical trials have been conducted and a few such trials for the treatment of LC by use of autologous and/or allogeneic cells are in progress. Overall, the results of these trials are indicative of clinical benefits with no adverse effect on the patients. This review focuses on the current status of BM stem-cell therapy for treatment of GLD and LC in experimental animals and human subjects. It also proposes safer approaches to immune-regulation in allogeneic transplantation of cells.
KW - Bone marrow stem cells
KW - Genetic liver disease
KW - Immunological tolerance
KW - Transdifferentiation
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U2 - 10.1007/s12072-013-9499-z
DO - 10.1007/s12072-013-9499-z
M3 - Review article
C2 - 26202499
AN - SCOPUS:84899916887
SN - 1936-0533
VL - 8
SP - 166
EP - 178
JO - Hepatology International
JF - Hepatology International
IS - 2
ER -