TY - JOUR
T1 - Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance
AU - Ganjoo, Shonik
AU - Puebla-Osorio, Nahum
AU - Nanez, Selene
AU - Hsu, Ethan
AU - Voss, Tiffany
AU - Barsoumian, Hampartsoum
AU - Duong, Lisa K.
AU - Welsh, James W.
AU - Cortez, Maria Angelica
N1 - Funding Information:
This work was supported U.S. Department of Defense (DOD) Lung Cancer Research Program (LRP; W81XWH-21-1-0336) to MC.
Publisher Copyright:
Copyright © 2022 Ganjoo, Puebla-Osorio, Nanez, Hsu, Voss, Barsoumian, Duong, Welsh and Cortez.
PY - 2022/10/24
Y1 - 2022/10/24
N2 - The TGF-β superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-β, has been extensively reviewed, other members of the family—namely bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs)—have not been as thoroughly investigated. Moreover, although the specific roles of TGF-β signaling in cancer immunology and immunotherapy resistance have been extensively reported, little is known of the roles of BMPs, activins, and GDFs in these domains. This review focuses on how these superfamily members influence key immune cells in cancer progression and resistance to treatment.
AB - The TGF-β superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-β, has been extensively reviewed, other members of the family—namely bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs)—have not been as thoroughly investigated. Moreover, although the specific roles of TGF-β signaling in cancer immunology and immunotherapy resistance have been extensively reported, little is known of the roles of BMPs, activins, and GDFs in these domains. This review focuses on how these superfamily members influence key immune cells in cancer progression and resistance to treatment.
KW - activins
KW - bone morphogenetic proteins
KW - cancer
KW - growth and differentiation factors
KW - immunotherapy
KW - TGF-β superfamily
UR - http://www.scopus.com/inward/record.url?scp=85141423728&partnerID=8YFLogxK
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U2 - 10.3389/fimmu.2022.1033642
DO - 10.3389/fimmu.2022.1033642
M3 - Review article
C2 - 36353620
AN - SCOPUS:85141423728
SN - 1664-3224
VL - 13
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 1033642
ER -