Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition

For The Late Effects Study Group

doi:10.1002/1097-0142(19801215)46:12<2603::AID-CNCR2820461212>3.0.CO;2-4

Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition

For The Late Effects Study Group

Genetics

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two‐mutation hypothesis. Studies of SMN in childhood permit us to make observations about the role of genetic factors and environmental mutagens in cancer etiology.

Original language	English (US)
Pages (from-to)	2603-2606
Number of pages	4
Journal	Cancer
Volume	46
Issue number	12
DOIs	https://doi.org/10.1002/1097-0142(19801215)46:12<2603::AID-CNCR2820461212>3.0.CO;2-4
State	Published - Dec 15 1980

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19801215)46:12<2603::AID-CNCR2820461212>3.0.CO;2-4

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title = "Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition",

abstract = "Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two‐mutation hypothesis. Studies of SMN in childhood permit us to make observations about the role of genetic factors and environmental mutagens in cancer etiology.",

author = "{For The Late Effects Study Group} and Meadows, {Anna T.} and Strong, {Louise C.} and Li, {Frederick P.} and D'Angio, {Giulio J.} and Odile Schweisguth and Freeman, {Arnold I.} and Jenkin, {R. D.T.} and Patricia Morris‐Jones and Nesbit, {Mark E.}",

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T1 - Bone sarcoma as a second malignant neoplasm in children

T2 - Influence of radiation and genetic predisposition

AU - For The Late Effects Study Group

AU - Meadows, Anna T.

AU - Strong, Louise C.

AU - Li, Frederick P.

AU - D'Angio, Giulio J.

AU - Schweisguth, Odile

AU - Freeman, Arnold I.

AU - Jenkin, R. D.T.

AU - Morris‐Jones, Patricia

AU - Nesbit, Mark E.

PY - 1980/12/15

Y1 - 1980/12/15

N2 - Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two‐mutation hypothesis. Studies of SMN in childhood permit us to make observations about the role of genetic factors and environmental mutagens in cancer etiology.

AB - Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors were present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease and therapy were analyzed by a two‐mutation hypothesis. Studies of SMN in childhood permit us to make observations about the role of genetic factors and environmental mutagens in cancer etiology.

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ER -

Bone sarcoma as a second malignant neoplasm in children: Influence of radiation and genetic predisposition

Abstract

ASJC Scopus subject areas

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