TY - JOUR
T1 - Brain and Ocular Abnormalities in Infants With In Utero Exposure to Cocaine and Other Street Drugs
AU - Dominguez, Rodrigo
AU - Aguirre Vila-Coro, Antonio
AU - Slopis, John M.
AU - Bohan, Timothy P.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1991/6
Y1 - 1991/6
N2 - We describe 10 infants with developmental delay and congenital cerebral anomalies who were found to have had in utero exposure to vasoactive drugs. Nine infants had ophthalmological abnormalities; these included strabismus, nystagmus, and/or hypoplastic optic discs. Six mothers used cocaine, one used cocaine and heroin, one used only heroin, one used amphetamine, and one used phenylpropanolamine. Each of these cerebral anomalies (agenesis of the corpus callosum, septo-optic dysplasia, schizencephaly, hydranencephaly, congenital hydrocephalus, porencephaly, and cerebral infarctions) can be attributed to insults at different stages of development. There appears to be a relationship between the time of prenatal drug exposure and the type of cerebral anomaly, evoking malformations, disruptions, or fetal strokes. Since many or possibly all of these anomalies are thought to have a vascular origin, it seems appropriate to implicate prenatal exposure to vasoactive drugs.
AB - We describe 10 infants with developmental delay and congenital cerebral anomalies who were found to have had in utero exposure to vasoactive drugs. Nine infants had ophthalmological abnormalities; these included strabismus, nystagmus, and/or hypoplastic optic discs. Six mothers used cocaine, one used cocaine and heroin, one used only heroin, one used amphetamine, and one used phenylpropanolamine. Each of these cerebral anomalies (agenesis of the corpus callosum, septo-optic dysplasia, schizencephaly, hydranencephaly, congenital hydrocephalus, porencephaly, and cerebral infarctions) can be attributed to insults at different stages of development. There appears to be a relationship between the time of prenatal drug exposure and the type of cerebral anomaly, evoking malformations, disruptions, or fetal strokes. Since many or possibly all of these anomalies are thought to have a vascular origin, it seems appropriate to implicate prenatal exposure to vasoactive drugs.
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U2 - 10.1001/archpedi.1991.02160060106030
DO - 10.1001/archpedi.1991.02160060106030
M3 - Article
C2 - 1709777
AN - SCOPUS:0025765020
SN - 0002-922X
VL - 145
SP - 688
EP - 695
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 6
ER -