Brain glucose metabolism in violent psychiatric patients: a preliminary study

Nora D. Volkow; Lawrence R. Tancredib; Cathel Grant; Hampton Gillespie; Allan Valentine; Nizar Mullani; Gene Jack Wang; Leo Hollister

doi:10.1016/0925-4927(95)02671-J

Brain glucose metabolism in violent psychiatric patients: a preliminary study

Nora D. Volkow, Lawrence R. Tancredib, Cathel Grant, Hampton Gillespie, Allan Valentine, Nizar Mullani, Gene Jack Wang, Leo Hollister

Psychiatry

Research output: Contribution to journal › Article › peer-review

150 Scopus citations

Abstract

Positron emission tomography with ¹⁸F-deoxyglucose was used to evaluate regional brain glucose metabolism in eight normal subjects and eight psychiatric patients with a history of repetitive violent behavior. Seven of the patients showed widespread areas of low brain metabolism. Although the location of the abnormal regions varied among patients, they showed significantly lower relative metabolic values in medial temporal and prefrontal cortices than did normal comparison subjects. These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior.

Original language	English (US)
Pages (from-to)	243-253
Number of pages	11
Journal	Psychiatry Research: Neuroimaging
Volume	61
Issue number	4
DOIs	https://doi.org/10.1016/0925-4927(95)02671-J
State	Published - Nov 10 1995

Keywords

Antisocial personality
Frontal lobe
Positron emission tomography
Schizophrenia
Temporal lobe
intermittent explosive disorder

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/0925-4927(95)02671-J

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title = "Brain glucose metabolism in violent psychiatric patients: a preliminary study",

abstract = "Positron emission tomography with 18F-deoxyglucose was used to evaluate regional brain glucose metabolism in eight normal subjects and eight psychiatric patients with a history of repetitive violent behavior. Seven of the patients showed widespread areas of low brain metabolism. Although the location of the abnormal regions varied among patients, they showed significantly lower relative metabolic values in medial temporal and prefrontal cortices than did normal comparison subjects. These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior.",

keywords = "Antisocial personality, Frontal lobe, Positron emission tomography, Schizophrenia, Temporal lobe, intermittent explosive disorder",

author = "Volkow, {Nora D.} and Tancredib, {Lawrence R.} and Cathel Grant and Hampton Gillespie and Allan Valentine and Nizar Mullani and Wang, {Gene Jack} and Leo Hollister",

note = "Funding Information: This research was supported in part by the U.S. Department of Energy under Contract DE-ACO2-76CH00016 and National Institutes of Health (AA 09481). The authors thank C. Wong and D. Patel for technical assistance.",

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T2 - a preliminary study

AU - Volkow, Nora D.

AU - Tancredib, Lawrence R.

AU - Grant, Cathel

AU - Gillespie, Hampton

AU - Valentine, Allan

AU - Mullani, Nizar

AU - Wang, Gene Jack

AU - Hollister, Leo

N1 - Funding Information: This research was supported in part by the U.S. Department of Energy under Contract DE-ACO2-76CH00016 and National Institutes of Health (AA 09481). The authors thank C. Wong and D. Patel for technical assistance.

PY - 1995/11/10

Y1 - 1995/11/10

N2 - Positron emission tomography with 18F-deoxyglucose was used to evaluate regional brain glucose metabolism in eight normal subjects and eight psychiatric patients with a history of repetitive violent behavior. Seven of the patients showed widespread areas of low brain metabolism. Although the location of the abnormal regions varied among patients, they showed significantly lower relative metabolic values in medial temporal and prefrontal cortices than did normal comparison subjects. These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior.

AB - Positron emission tomography with 18F-deoxyglucose was used to evaluate regional brain glucose metabolism in eight normal subjects and eight psychiatric patients with a history of repetitive violent behavior. Seven of the patients showed widespread areas of low brain metabolism. Although the location of the abnormal regions varied among patients, they showed significantly lower relative metabolic values in medial temporal and prefrontal cortices than did normal comparison subjects. These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior.

KW - Antisocial personality

KW - Frontal lobe

KW - Positron emission tomography

KW - Schizophrenia

KW - Temporal lobe

KW - intermittent explosive disorder

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Brain glucose metabolism in violent psychiatric patients: a preliminary study

Abstract

Keywords

ASJC Scopus subject areas

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