Abstract
Purpose of Review: The purpose of this review is to summarize recent developments in PET imaging of neuropathologies underlying HIV-associated neurocognitive dysfunction (HAND). We concentrate on the recent post antiretroviral era (ART), highlighting clinical and preclinical brain PET imaging studies. Recent Findings: In the post ART era, PET imaging has been used to better understand perturbations of glucose metabolism, neuroinflammation, the function of neurotransmitter systems, and amyloid/tau protein deposition in the brains of HIV-infected patients and HIV animal models. Preclinical and translational findings from those studies shed a new light on the complex pathophysiology underlying HAND. Summary: The molecular imaging capabilities of PET in neuro-HIV are great complements for structural imaging modalities. Recent and future PET imaging studies can improve our understanding of neuro-HIV and provide biomarkers of disease progress that could be used as surrogate endpoints in the evaluation of the effectiveness of potential neuroprotective therapies.
Original language | English (US) |
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Pages (from-to) | 66-75 |
Number of pages | 10 |
Journal | Current HIV/AIDS Reports |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Feb 15 2019 |
Keywords
- Amyloid deposition
- Brain PET imaging
- HIV
- HIV-associated neurocognitive disorder (HAND)
- Inflammation
- Neurotransmitters
ASJC Scopus subject areas
- Virology
- Infectious Diseases