Abstract
The last 5 years have seen significant advances in our understanding of the molecular pathogenesis of B-cell lymphomas. This has led to the emergence of a large number of new therapeutic agents exploiting precise aspects of the tumor cells signaling pathways, surface antigens or microenvironment. The purpose of this comprehensive review is to provide a detailed analysis of the breakthrough agents in the field, with a focus on recent clinical data. We describe agents targeting the B-cell receptor pathway, Bcl-2 inhibitors, emerging epigenetic therapies, new monoclonal antibodies and antibody drug conjugates, selective inhibitors of nuclear export, agents targeting the programmed cell death axis and chimeric antigen receptor T cells.
Original language | English (US) |
---|---|
Article number | mdw015 |
Pages (from-to) | 778-787 |
Number of pages | 10 |
Journal | Annals of Oncology |
Volume | 27 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2016 |
Keywords
- Ibrutinib
- Idelalisib
- Lymphomas
- Novel agents
- Treatment
- Venetoclax
ASJC Scopus subject areas
- Hematology
- Oncology