TY - JOUR
T1 - Breast Cancer Before Age 40 Years
AU - Anders, Carey K.
AU - Johnson, Rebecca
AU - Litton, Jennifer
AU - Phillips, Marianne
AU - Bleyer, Archie
PY - 2009/6
Y1 - 2009/6
N2 - Approximately 7% of women with breast cancer are diagnosed before the age of 40 years, and this disease accounts for more than 40% of all cancer in women in this age group. Survival rates are worse when compared to those in older women, and multivariate analysis has shown younger age to be an independent predictor of adverse outcome. Inherited syndromes, specifically BRCA1 and BRCA2, must be considered when developing treatment algorithms for younger women. Chemotherapy, endocrine, and local therapies have the potential to significantly impact both the physiologic health-including future fertility, premature menopause, and bone health-and the psychological health of young women as they face a diagnosis of breast cancer.
AB - Approximately 7% of women with breast cancer are diagnosed before the age of 40 years, and this disease accounts for more than 40% of all cancer in women in this age group. Survival rates are worse when compared to those in older women, and multivariate analysis has shown younger age to be an independent predictor of adverse outcome. Inherited syndromes, specifically BRCA1 and BRCA2, must be considered when developing treatment algorithms for younger women. Chemotherapy, endocrine, and local therapies have the potential to significantly impact both the physiologic health-including future fertility, premature menopause, and bone health-and the psychological health of young women as they face a diagnosis of breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=65549132756&partnerID=8YFLogxK
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U2 - 10.1053/j.seminoncol.2009.03.001
DO - 10.1053/j.seminoncol.2009.03.001
M3 - Article
C2 - 19460581
AN - SCOPUS:65549132756
SN - 0093-7754
VL - 36
SP - 237
EP - 249
JO - Seminars in oncology
JF - Seminars in oncology
IS - 3
ER -