TY - JOUR
T1 - Breast Cancer Genetics and Cancer Control
T2 - Tumor Association
AU - Lynch, Henry T.
AU - Lynch, Jane
AU - Lynch, Pat
PY - 1975/10
Y1 - 1975/10
N2 - Verified breast cancer was present in a father, his mother, and his daughter. His son had a brain tumor (by history) and his grandson, (the son of the affected daughter), had a histologically verified rhabdomyosarcoma. This familial aggregation of cancers (except for leukemia, which is absent) is consistent with a newly described familial breast cancer syndrome. A single pleiotropic, dominantly transmitted gene, possibly interacting with carcinogenic factors, such as an oncogenic virus, may be the cause. A cancer-control potential exists for tumor associations such as those exhibited in this kindred, as well as for other cancer genetic syndromes where careful consideration is given to all histologic varieties of cancer.
AB - Verified breast cancer was present in a father, his mother, and his daughter. His son had a brain tumor (by history) and his grandson, (the son of the affected daughter), had a histologically verified rhabdomyosarcoma. This familial aggregation of cancers (except for leukemia, which is absent) is consistent with a newly described familial breast cancer syndrome. A single pleiotropic, dominantly transmitted gene, possibly interacting with carcinogenic factors, such as an oncogenic virus, may be the cause. A cancer-control potential exists for tumor associations such as those exhibited in this kindred, as well as for other cancer genetic syndromes where careful consideration is given to all histologic varieties of cancer.
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U2 - 10.1001/archsurg.1975.01360160065010
DO - 10.1001/archsurg.1975.01360160065010
M3 - Article
C2 - 1191014
AN - SCOPUS:0016728011
SN - 0004-0010
VL - 110
SP - 1227
EP - 1229
JO - Archives of Surgery
JF - Archives of Surgery
IS - 10
ER -