Breast cancer stem cells

Kazuharu Kai; Yoshimi Arima; Toshio Kamiya; Hideyuki Saya

doi:10.1007/s12282-009-0176-y

Breast cancer stem cells

Kazuharu Kai, Yoshimi Arima, Toshio Kamiya, Hideyuki Saya

Breast Medical Oncology

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44- positive (CD24^-/ CD44⁺) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.

Original language	English (US)
Pages (from-to)	80-85
Number of pages	6
Journal	Breast Cancer
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s12282-009-0176-y
State	Published - Apr 2010

Keywords

Epithelial to mesenchymal transition (EMT)
Niche
Self-renewal
Somatic (tissue-specific) stem cell

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

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10.1007/s12282-009-0176-y

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title = "Breast cancer stem cells",

abstract = "Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44- positive (CD24-/ CD44+) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.",

keywords = "Epithelial to mesenchymal transition (EMT), Niche, Self-renewal, Somatic (tissue-specific) stem cell",

author = "Kazuharu Kai and Yoshimi Arima and Toshio Kamiya and Hideyuki Saya",

note = "Funding Information: This work was supported in part by the following NIH grants R01CA070896 , R01CA075503 , R01CA107382 , R01CA132115 , and R01CA086072 (R.G.P.). The Kimmel Cancer Center was supported by the NIH Cancer Center Core Grant P30CA56036 (to R.G.P.). This project is funded in part from the Marian C. Falk Medical Research Trust and a grant from the Pennsylvania Department of Health (R.G.P.). ",

year = "2010",

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doi = "10.1007/s12282-009-0176-y",

language = "English (US)",

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AU - Kai, Kazuharu

AU - Arima, Yoshimi

AU - Kamiya, Toshio

AU - Saya, Hideyuki

N1 - Funding Information: This work was supported in part by the following NIH grants R01CA070896 , R01CA075503 , R01CA107382 , R01CA132115 , and R01CA086072 (R.G.P.). The Kimmel Cancer Center was supported by the NIH Cancer Center Core Grant P30CA56036 (to R.G.P.). This project is funded in part from the Marian C. Falk Medical Research Trust and a grant from the Pennsylvania Department of Health (R.G.P.).

PY - 2010/4

Y1 - 2010/4

N2 - Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44- positive (CD24-/ CD44+) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.

AB - Since the initial discovery of leukemia stem cells nearly a decade ago, a great deal of cancer research has focused on the identification of cancer stem cells (CSCs) in many types of solid tumors, including breast cancer. Through analysis of cell surface markers and xenotransplant models, a subpopulation of putative human breast cancer stem cells (BCSCs) that is CD24-negative/CD44- positive (CD24-/ CD44+) and bears high aldehyde dehydrogenase 1 activity has been isolated in clinical samples of breast cancer tissues. Human BCSCs are considered to be derived from basal cells that reside in the basal membranes of alveolar units in human adult mammary glands. Furthermore, BCSCs have been shown to express higher levels of oxidative stress-responsive genes, which could confer part of their ability to resist anti-cancer therapy, than non-CSCs. The emerging picture of the biological properties of BCSCs would contribute for devising innovative therapies for breast cancer, targeting the intrinsic and extrinsic factors that maintain the BCSCs.

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Breast cancer stem cells

Abstract

Keywords

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