TY - JOUR
T1 - Brief communication
T2 - Early changes in chromosomal number and structure after treatment of fetal hamster cultures with transforming doses of polycyclic hydrocarbons
AU - Benedict, William F.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1972/8
Y1 - 1972/8
N2 - Fetal hamster cells were exposed to transforming doses of the polycyclic hydrocarbons, 7, 12-dimethylbenz[a]anthracene, benzo[a]pyrene, 3-hydroxybenzo[o]pyrene, and benz[a]anthracene. On cytogenetic analysis, metaphases were found with abnormalities in chromosomal number and structure within 24-72 hours after treatment. These rapidly appearing chromosomal changes may be important in cell transformation by polycyclic hydrocarbons.—J Natl Cancer Inst.
AB - Fetal hamster cells were exposed to transforming doses of the polycyclic hydrocarbons, 7, 12-dimethylbenz[a]anthracene, benzo[a]pyrene, 3-hydroxybenzo[o]pyrene, and benz[a]anthracene. On cytogenetic analysis, metaphases were found with abnormalities in chromosomal number and structure within 24-72 hours after treatment. These rapidly appearing chromosomal changes may be important in cell transformation by polycyclic hydrocarbons.—J Natl Cancer Inst.
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U2 - 10.1093/jnci/49.2.585
DO - 10.1093/jnci/49.2.585
M3 - Article
C2 - 5076831
AN - SCOPUS:0015386011
SN - 0027-8874
VL - 49
SP - 585
EP - 590
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 2
ER -