TY - JOUR
T1 - Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients
T2 - Correlation of Computed Tomography Findings with Bronchiolitis Obliterans Syndrome Stage
AU - Choi, Yo Won
AU - Rossi, Santiago E.
AU - Palmer, Scott M.
AU - DeLong, David
AU - Erasmus, Jeremy J.
AU - McAdams, H. Page
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/4
Y1 - 2003/4
N2 - The purpose of this study was to correlate the extent of computed tomographic (CT) findings with the severity of respiratory dysfunction in lung transplant recipients with bronchiolitis obliterans syndrome (BOS). Eighty-nine conventional and 61 thin-section CT scans performed in 44 transplant recipients (17 bilateral, 27 single) with BOS were reviewed for mosaic attenuation, degree of bronchial dilation, bronchial thickening, central and peripheral bronchiectasis, mucus plugging, and air trapping. Findings on conventional and thin-section CT scans were correlated with BOS stage for bilateral and single-lung transplant recipients. In bilateral-lung recipients, a significant correlation existed, although weak, between BOS stage and findings of degree of bronchial dilation (P < 0.01), bronchial wall thickening (P = 0.01), peripheral bronchiectasis (P = 0.01), and mosaic attenuation (P = 0.01) on conventional CT; and bronchial wall thickening (P = 0.01) and mosaic attenuation (P = 0.03) on thin-section CT. In single-lung recipients, BOS stage correlated only with the finding of central bronchiectasis (P = 0.02) on conventional CT scans. No correlation was found between the extent of air trapping and BOS stage in either single- or bilateral-lung transplant recipients. CT findings are relatively poor indices of airflow obstruction in lung transplant recipients with BOS, particularly in those with single-lung transplants for emphysema.
AB - The purpose of this study was to correlate the extent of computed tomographic (CT) findings with the severity of respiratory dysfunction in lung transplant recipients with bronchiolitis obliterans syndrome (BOS). Eighty-nine conventional and 61 thin-section CT scans performed in 44 transplant recipients (17 bilateral, 27 single) with BOS were reviewed for mosaic attenuation, degree of bronchial dilation, bronchial thickening, central and peripheral bronchiectasis, mucus plugging, and air trapping. Findings on conventional and thin-section CT scans were correlated with BOS stage for bilateral and single-lung transplant recipients. In bilateral-lung recipients, a significant correlation existed, although weak, between BOS stage and findings of degree of bronchial dilation (P < 0.01), bronchial wall thickening (P = 0.01), peripheral bronchiectasis (P = 0.01), and mosaic attenuation (P = 0.01) on conventional CT; and bronchial wall thickening (P = 0.01) and mosaic attenuation (P = 0.03) on thin-section CT. In single-lung recipients, BOS stage correlated only with the finding of central bronchiectasis (P = 0.02) on conventional CT scans. No correlation was found between the extent of air trapping and BOS stage in either single- or bilateral-lung transplant recipients. CT findings are relatively poor indices of airflow obstruction in lung transplant recipients with BOS, particularly in those with single-lung transplants for emphysema.
KW - Bronchiolitis obliterans syndrome
KW - Obliterative bronchiolitis
KW - Transplant
UR - http://www.scopus.com/inward/record.url?scp=0142122228&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0142122228&partnerID=8YFLogxK
U2 - 10.1097/00005382-200304000-00003
DO - 10.1097/00005382-200304000-00003
M3 - Article
C2 - 12700480
AN - SCOPUS:0142122228
SN - 0883-5993
VL - 18
SP - 72
EP - 79
JO - Journal of Thoracic Imaging
JF - Journal of Thoracic Imaging
IS - 2
ER -