TY - JOUR
T1 - Butterfly glioblastomas
T2 - A retrospective review and qualitative assessment of outcomes
AU - Dziurzynski, Kristine
AU - Blas-Boria, David
AU - Suki, Dima
AU - Cahill, Daniel P.
AU - Prabhu, Sujit S.
AU - Puduvalli, Vinay
AU - Levine, Nicholas
PY - 2012/9
Y1 - 2012/9
N2 - To address a paucity of literature and treatment guidelines regarding the management of butterfly glioblastomas, we performed a ten year retrospective analysis of data from twenty-three consecutive patients treated for this disease at a single institution. Clinical characteristics and outcomes were assessed. Median age was 59 years; 52 % were female; median preoperative Karnofsky performance score (KPS) was 80. Twelve patients underwent biopsy and eleven underwent surgical decompression. The median tumor volume for the biopsy group was 60.6 cm3 and for the surgically decompressed group 40.5 cm3. In the biopsy group, five patients received adjuvant therapy but one died prior to its completion; two died prior to the initiation of adjuvant therapy and five were lost to follow up. In the surgical decompression group, seven patients received adjuvant therapy, one died prior to the initiation of adjuvant therapy, two were treated with palliative measures only, and one was lost to follow up. Kaplan-Meier estimates of overall median post surgical-survival of the whole group was 180 days, the biopsy group 48 days, and the surgically decompressed group 265 days (p = 0.14). Our results show that there was a higher median survival in the surgically decompressed group; but a direct correlation could not be established, and that the median KPS did not improve in either group after treatment. A larger multicenter review is required to quantitatively assess the factors, including tumor biomarkers that are associated with patient outcome.
AB - To address a paucity of literature and treatment guidelines regarding the management of butterfly glioblastomas, we performed a ten year retrospective analysis of data from twenty-three consecutive patients treated for this disease at a single institution. Clinical characteristics and outcomes were assessed. Median age was 59 years; 52 % were female; median preoperative Karnofsky performance score (KPS) was 80. Twelve patients underwent biopsy and eleven underwent surgical decompression. The median tumor volume for the biopsy group was 60.6 cm3 and for the surgically decompressed group 40.5 cm3. In the biopsy group, five patients received adjuvant therapy but one died prior to its completion; two died prior to the initiation of adjuvant therapy and five were lost to follow up. In the surgical decompression group, seven patients received adjuvant therapy, one died prior to the initiation of adjuvant therapy, two were treated with palliative measures only, and one was lost to follow up. Kaplan-Meier estimates of overall median post surgical-survival of the whole group was 180 days, the biopsy group 48 days, and the surgically decompressed group 265 days (p = 0.14). Our results show that there was a higher median survival in the surgically decompressed group; but a direct correlation could not be established, and that the median KPS did not improve in either group after treatment. A larger multicenter review is required to quantitatively assess the factors, including tumor biomarkers that are associated with patient outcome.
KW - Bifrontal glioma
KW - Biftrontal glioblastoma
KW - Bihemispheric glioma
KW - Butterfly glioma
KW - Butterfly gliomblastoma
KW - Corpus callosum glioblastoma
UR - http://www.scopus.com/inward/record.url?scp=84866021510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866021510&partnerID=8YFLogxK
U2 - 10.1007/s11060-012-0926-0
DO - 10.1007/s11060-012-0926-0
M3 - Review article
C2 - 22806339
AN - SCOPUS:84866021510
SN - 0167-594X
VL - 109
SP - 555
EP - 563
JO - Journal of neuro-oncology
JF - Journal of neuro-oncology
IS - 3
ER -