Bypass specialists operate together

Kei Ichi Takata; Richard D. Wood

doi:10.1038/emboj.2008.303

Bypass specialists operate together

Kei Ichi Takata, Richard D. Wood

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (polzζ) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.

Original language	English (US)
Pages (from-to)	313-314
Number of pages	2
Journal	EMBO Journal
Volume	28
Issue number	4
DOIs	https://doi.org/10.1038/emboj.2008.303
State	Published - Feb 18 2009

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.1038/emboj.2008.303

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abstract = "New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (polzζ) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.",

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Bypass specialists operate together

Abstract

ASJC Scopus subject areas

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