TY - JOUR
T1 - c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
AU - Nie, Zuqin
AU - Hu, Gangqing
AU - Wei, Gang
AU - Cui, Kairong
AU - Yamane, Arito
AU - Resch, Wolfgang
AU - Wang, Ruoning
AU - Green, Douglas R.
AU - Tessarollo, Lino
AU - Casellas, Rafael
AU - Zhao, Keji
AU - Levens, David
N1 - Publisher Copyright:
© 2012 Elsevier Inc.
PY - 2012/9/28
Y1 - 2012/9/28
N2 - The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or organismal levels via regulation of numerous target genes. No principle yet unifies Myc action due partly to an incomplete inventory and functional accounting of Myc's targets. To observe Myc target expression and function in a system where Myc is temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II, and chromatin modifications were compared during lymphocyte activation and in ES cells as well. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off specifier of gene activity, but is a nonlinear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.
AB - The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism, and differentiation at the cellular, tissue, or organismal levels via regulation of numerous target genes. No principle yet unifies Myc action due partly to an incomplete inventory and functional accounting of Myc's targets. To observe Myc target expression and function in a system where Myc is temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II, and chromatin modifications were compared during lymphocyte activation and in ES cells as well. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off specifier of gene activity, but is a nonlinear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.
UR - http://www.scopus.com/inward/record.url?scp=84867010006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867010006&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2012.08.033
DO - 10.1016/j.cell.2012.08.033
M3 - Article
C2 - 23021216
AN - SCOPUS:84867010006
SN - 0092-8674
VL - 151
SP - 68
EP - 79
JO - Cell
JF - Cell
IS - 1
ER -