Abstract
The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit ros-specific RNA using sensitive techniques such as RNAse protection and in situ hybridization. The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine. The data provide evidence for a role of c-ros in the obligate cell-cell interactions that characterize the morphogenic induction and proliferation of epithelial cells in the kidney, intestine and lung. The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions.
Original language | English (US) |
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Pages (from-to) | 11-20 |
Number of pages | 10 |
Journal | Development |
Volume | 115 |
Issue number | 1 |
State | Published - May 1992 |
Keywords
- Embryogenesis
- In situ
- Proto-oncogene
- Tyrosine kinase
- c-ros
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology