Abstract
Many kinases are required for progression through the eukaryotic cell cycle. The Aurora kinases comprise a highly conserved family of serine/threonine kinases that have been Implicated in chromosome segregation and cytokinesis in several organisms. We have isolated a sterile Caenorhabditis elegans mutant in which the majority of the locus encoding the Aurora A kinase air-1 has been deleted. Complementation tests with previously isolated sterile mutations in the air-1 genetic interval demonstrate that the air-1 and let-412 loci are Identical. Previous analysis of AIR-1 function by RNA-mediated interference (RNAi) has shown that AIR-1 is required for embryonic survival. The characterization of the three sterile air-1 mutant alleles described here extends these studies by revealing an allelic series that differentially affects postembryonic cell divisions and germllne development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 244-250 |
| Number of pages | 7 |
| Journal | Genesis (United States) |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2002 |
Keywords
- AIR-1
- Aurora kinase
- Cell division
- Let-412
- Meiotic chromosomes
- Stu
ASJC Scopus subject areas
- Genetics
- Endocrinology
- Cell Biology