Callyspongiolide, a cytotoxic macrolide from the marine sponge callyspongia sp.

Cong Dat Pham; Rudolf Hartmann; Philip Böhler; Björn Stork; Sebastian Wesselborg; Wenhan Lin; Daowan Lai; Peter Proksch

doi:10.1021/ol403241v

Callyspongiolide, a cytotoxic macrolide from the marine sponge callyspongia sp.

Cong Dat Pham, Rudolf Hartmann, Philip Böhler, Björn Stork, Sebastian Wesselborg, Wenhan Lin, Daowan Lai, Peter Proksch

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

Original language	English (US)
Pages (from-to)	266-269
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	1
DOIs	https://doi.org/10.1021/ol403241v
State	Published - Jan 3 2014
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol403241v

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abstract = "A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.",

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AU - Pham, Cong Dat

AU - Hartmann, Rudolf

AU - Böhler, Philip

AU - Stork, Björn

AU - Wesselborg, Sebastian

AU - Lin, Wenhan

AU - Lai, Daowan

AU - Proksch, Peter

PY - 2014/1/3

Y1 - 2014/1/3

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AB - A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

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Callyspongiolide, a cytotoxic macrolide from the marine sponge callyspongia sp.

Abstract

ASJC Scopus subject areas

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