TY - JOUR
T1 - Can a female donor for a male recipient decrease the relapse rate for patients with acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation?
AU - Kongtim, Piyanuch
AU - Di Stasi, Antonio
AU - Rondon, Gabriela
AU - Chen, Julianne
AU - Adekola, Kehinde
AU - Popat, Uday
AU - Oran, Betul
AU - Kebriaei, Partow
AU - Andersson, Borje S.
AU - Champlin, Richard E.
AU - Ciurea, Stefan O.
N1 - Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - The mismatched minor histocompatibility antigens present on Y chromosome (H-Y) in male recipients receiving stem cells from female donors may contribute to the graft-versus-leukemia effect and results in a reduced relapse rate, especially in patients with high-risk disease. We retrospectively compared the outcomes of male patients with acute myeloid leukemia who received an allogeneic hematopoietic stem cell transplant (HSCT) from female donors (F-M) (174 patients) versus other gender combinations (667 patients). Median age was 50years (range, 18 to 74years). For the whole group, the 1-year cumulative incidence of relapse was significantly lower in F-M group (34.1% versus 41.3%, P= .044), whereas nonrelapse mortality (NRM) was higher (23.2% versus 15.7%, P= .004). For patients younger than 50years beyond first complete remission, the F-M group was associated with lower relapse rate (42.5% versus 55.2%, P= .045) whereas NRM was not significantly different (35.8% versus 25.5%, P= .141). Although survival was not significantly improved, transplantation from a female donor for male recipient was associated with a lower relapse rate. When relapse is the most common concern for treatment failure, especially for younger patients, a female donor for a male recipient might be beneficial to decrease relapse rate after transplantation. Future studies are needed to explore how the H-Y mismatch may improve survival after transplantation.
AB - The mismatched minor histocompatibility antigens present on Y chromosome (H-Y) in male recipients receiving stem cells from female donors may contribute to the graft-versus-leukemia effect and results in a reduced relapse rate, especially in patients with high-risk disease. We retrospectively compared the outcomes of male patients with acute myeloid leukemia who received an allogeneic hematopoietic stem cell transplant (HSCT) from female donors (F-M) (174 patients) versus other gender combinations (667 patients). Median age was 50years (range, 18 to 74years). For the whole group, the 1-year cumulative incidence of relapse was significantly lower in F-M group (34.1% versus 41.3%, P= .044), whereas nonrelapse mortality (NRM) was higher (23.2% versus 15.7%, P= .004). For patients younger than 50years beyond first complete remission, the F-M group was associated with lower relapse rate (42.5% versus 55.2%, P= .045) whereas NRM was not significantly different (35.8% versus 25.5%, P= .141). Although survival was not significantly improved, transplantation from a female donor for male recipient was associated with a lower relapse rate. When relapse is the most common concern for treatment failure, especially for younger patients, a female donor for a male recipient might be beneficial to decrease relapse rate after transplantation. Future studies are needed to explore how the H-Y mismatch may improve survival after transplantation.
KW - Busulfan conditioning
KW - Graft-versus-host disease
KW - Graft-versus-leukemia effect
KW - Hematopoietic stem cell transplantation
KW - Minor histocompatibility antigens
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U2 - 10.1016/j.bbmt.2014.12.018
DO - 10.1016/j.bbmt.2014.12.018
M3 - Article
C2 - 25540936
AN - SCOPUS:84924232414
SN - 1083-8791
VL - 21
SP - 713
EP - 719
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 4
ER -