TY - JOUR
T1 - Can preoperative computed tomography predict tissue origin of primary maxillary cancer?
AU - Yuan, Ying
AU - Wang, Jingbo
AU - Wu, Yingwei
AU - Li, Guojun
AU - Tao, Xiaofeng
N1 - Publisher Copyright:
Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Based on the histopathologic origin, malignant maxillary neoplasms may share some clinical characteristics but have different biological behavior, treatments, and prognoses. The aim of the present study was to explore the association between CT characteristics and tissue origin of primary maxillary cancer (MC). A retrospective review of CT findings was performed in patients diagnosed with MCbetween January 1, 2005 and December 31, 2013. Univariate and multivariable logistic regression analyses were performed to determine the association between tissue of origin and CT characteristics, with adjustment for possible confounding factors. A total of 164 patients (70 male, 94 female, age: 46.8±18.3 years) were included. Patients were divided into epithelial (n=88) and nonepithelial (n=76), or odontogenic (n=15) and nonodontogenic (n=149) groups. After adjusting for age, sex, smoking status, alcohol use, tumor size, and stage in the multivariable logistic regression model, the lesions with cortical bowing were found more likely to be epithelial (odds ratio [OR]=7.0, 95% confidence interval [CI], 1.4-36.1) than nonepithelial origin, while lesions with cervical lymphadenopathy were more associated with a nonodontogenic origin (OR=12.6, 95% CI, 1.1-140.0) rather than odontogenic. Among epithelial cancers, lesions with cortical bowing were 14 times more likely to be salivary gland-type (OR=13.8, 95% CI, 1.3-141.5). CT characteristics of cortical bowing and cervical lymphadenopathy might be suggestive of tissue origin in MC. Larger prospective studies are warranted to further examine the association.
AB - Based on the histopathologic origin, malignant maxillary neoplasms may share some clinical characteristics but have different biological behavior, treatments, and prognoses. The aim of the present study was to explore the association between CT characteristics and tissue origin of primary maxillary cancer (MC). A retrospective review of CT findings was performed in patients diagnosed with MCbetween January 1, 2005 and December 31, 2013. Univariate and multivariable logistic regression analyses were performed to determine the association between tissue of origin and CT characteristics, with adjustment for possible confounding factors. A total of 164 patients (70 male, 94 female, age: 46.8±18.3 years) were included. Patients were divided into epithelial (n=88) and nonepithelial (n=76), or odontogenic (n=15) and nonodontogenic (n=149) groups. After adjusting for age, sex, smoking status, alcohol use, tumor size, and stage in the multivariable logistic regression model, the lesions with cortical bowing were found more likely to be epithelial (odds ratio [OR]=7.0, 95% confidence interval [CI], 1.4-36.1) than nonepithelial origin, while lesions with cervical lymphadenopathy were more associated with a nonodontogenic origin (OR=12.6, 95% CI, 1.1-140.0) rather than odontogenic. Among epithelial cancers, lesions with cortical bowing were 14 times more likely to be salivary gland-type (OR=13.8, 95% CI, 1.3-141.5). CT characteristics of cortical bowing and cervical lymphadenopathy might be suggestive of tissue origin in MC. Larger prospective studies are warranted to further examine the association.
KW - Computed tomography
KW - Epithelial
KW - Maxilla
KW - Neoplasm
KW - Odontogenic
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U2 - 10.1097/MD.0000000000004831
DO - 10.1097/MD.0000000000004831
M3 - Article
C2 - 27749536
AN - SCOPUS:84995595662
SN - 0025-7974
VL - 95
JO - Medicine (United States)
JF - Medicine (United States)
IS - 40
M1 - e4831
ER -