Abstract
Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-depth analysis of a public lung adenocarcinoma single-cell transcriptome dataset. Edits significantly enriched in cancer cells compared to other cell types have the potential to inhibit innate immune response and to predict poor therapeutic response and prognosis in patients treated with targeted therapies.
Original language | English (US) |
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Pages (from-to) | 351-353 |
Number of pages | 3 |
Journal | Cancer Research |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 2023 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research
MD Anderson CCSG core facilities
- Bioinformatics Shared Resource