TY - JOUR
T1 - Cancer diagnosis in first-degree relatives and non-small cell lung cancer risk
T2 - Results from a multi-centre case-control study in Europe
AU - Cassidy, Adrian
AU - Balsan, Jessica
AU - Vesin, Aurélien
AU - Wu, Xifeng
AU - Liloglou, Triantafillos
AU - Brambilla, Christian
AU - Timsit, Jean François
AU - Field, John K.
N1 - Funding Information:
We thank the individuals who participated in this research and the clinicians and support staff who made this study possible. The European Early Lung Cancer study was supported by a Framework V grant from the European Union (QLG1-CT-2002-01735).
PY - 2009/11
Y1 - 2009/11
N2 - Because aggregation of cancers at different sites can occur in families, cancer could be considered as a broad phenotype with shared genetic factors. Here, we report results from a multi-centre case-control study of non-small cell lung cancer (NSCLC), with particular emphasis on a history of cancer in first-degree relatives and the risk of lung cancer. From 2002 to 2006, 733 NSCLC patients treated surgically were recruited in 8 European countries and matched to 1312 controls, by centre, sex and age. We used multivariate conditional logistic regression models to test the association between a history of cancer in first-degree relatives and risk of NSCLC. A family history of lung cancer was associated with an odds ratio (OR) for early-onset (54 years or younger) NSCLC of 4.72 (95% confidence interval [CI] = 1.02-21.90). A family history of gastric cancer was associated with an OR for NSCLC of 1.82 (95% CI = 1.08-3.06) and for late-onset (55 years or older) NSCLC of 2.92 (95% CI = 1.10-7.75). Our findings provide further evidence of a familial predisposition to lung cancer and support the hypothesis that family history is a significant risk factor for the disease. Because of the inherent potential for bias in familial case-control study design, cautious interpretation is warranted.
AB - Because aggregation of cancers at different sites can occur in families, cancer could be considered as a broad phenotype with shared genetic factors. Here, we report results from a multi-centre case-control study of non-small cell lung cancer (NSCLC), with particular emphasis on a history of cancer in first-degree relatives and the risk of lung cancer. From 2002 to 2006, 733 NSCLC patients treated surgically were recruited in 8 European countries and matched to 1312 controls, by centre, sex and age. We used multivariate conditional logistic regression models to test the association between a history of cancer in first-degree relatives and risk of NSCLC. A family history of lung cancer was associated with an odds ratio (OR) for early-onset (54 years or younger) NSCLC of 4.72 (95% confidence interval [CI] = 1.02-21.90). A family history of gastric cancer was associated with an OR for NSCLC of 1.82 (95% CI = 1.08-3.06) and for late-onset (55 years or older) NSCLC of 2.92 (95% CI = 1.10-7.75). Our findings provide further evidence of a familial predisposition to lung cancer and support the hypothesis that family history is a significant risk factor for the disease. Because of the inherent potential for bias in familial case-control study design, cautious interpretation is warranted.
KW - Family history
KW - Genetic susceptibility
KW - Non-small cell lung cancer
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U2 - 10.1016/j.ejca.2009.05.006
DO - 10.1016/j.ejca.2009.05.006
M3 - Article
C2 - 19482469
AN - SCOPUS:70350597708
SN - 0959-8049
VL - 45
SP - 3047
EP - 3053
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 17
ER -