Cancer drug discovery faces the FACT

Giulio F. Draetta; Ronald A. DePinho

doi:10.1126/scitranslmed.3002822

Cancer drug discovery faces the FACT

Giulio F. Draetta, Ronald A. DePinho

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules - curaxins - that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.

Original language	English (US)
Article number	95ps34
Journal	Science translational medicine
Volume	3
Issue number	95
DOIs	https://doi.org/10.1126/scitranslmed.3002822
State	Published - Aug 10 2011
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1126/scitranslmed.3002822

Cite this

@article{bfcbcc3ae05f40198ca9760cdb250e35,

title = "Cancer drug discovery faces the FACT",

abstract = "In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules - curaxins - that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.",

author = "Draetta, {Giulio F.} and DePinho, {Ronald A.}",

year = "2011",

month = aug,

day = "10",

doi = "10.1126/scitranslmed.3002822",

language = "English (US)",

volume = "3",

journal = "Science translational medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

number = "95",

}

TY - JOUR

T1 - Cancer drug discovery faces the FACT

AU - Draetta, Giulio F.

AU - DePinho, Ronald A.

PY - 2011/8/10

Y1 - 2011/8/10

N2 - In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules - curaxins - that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.

AB - In this issue of Science Translational Medicine, Gasparian et al. use a clever cell-based screen to identify a family of DNA-binding small molecules - curaxins - that inhibit tumor cell growth and division. The curaxins' mechanism of action pinpoints a new chromatin-remodeling factor as a therapeutic target for cancer.

UR - http://www.scopus.com/inward/record.url?scp=80051745066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051745066&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.3002822

DO - 10.1126/scitranslmed.3002822

M3 - Short survey

C2 - 21832237

AN - SCOPUS:80051745066

SN - 1946-6234

VL - 3

JO - Science translational medicine

JF - Science translational medicine

IS - 95

M1 - 95ps34

ER -

Cancer drug discovery faces the FACT

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this