Cancer extracellular matrix proteins regulate tumour immunity

Alex Gordon-Weeks; Arseniy E. Yuzhalin

doi:10.3390/cancers12113331

Cancer extracellular matrix proteins regulate tumour immunity

Alex Gordon-Weeks, Arseniy E. Yuzhalin

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

The extracellular matrix (ECM) plays an increasingly recognised role in the development and progression of cancer. Whilst significant progress has been made in targeting aspects of the tumour microenvironment such as tumour immunity and angiogenesis, there are no therapies that address the cancer ECM. Importantly, immune function relies heavily on the structure, physics and composition of the ECM, indicating that cancer ECM and immunity are mechanistically inseparable. In this review we highlight mechanisms by which the ECM shapes tumour immunity, identifying potential therapeutic targets within the ECM. These data indicate that to fully realise the potential of cancer immunotherapy, the cancer ECM requires simultaneous consideration.

Original language	English (US)
Article number	3331
Pages (from-to)	1-25
Number of pages	25
Journal	Cancers
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/cancers12113331
State	Published - Nov 2020

Keywords

Cancer
Collagen
Extracellular matrix
Fibronectin
Immune
Immune checkpoint
Immunity
Metastasis
Microenvironment
Therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers12113331

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title = "Cancer extracellular matrix proteins regulate tumour immunity",

abstract = "The extracellular matrix (ECM) plays an increasingly recognised role in the development and progression of cancer. Whilst significant progress has been made in targeting aspects of the tumour microenvironment such as tumour immunity and angiogenesis, there are no therapies that address the cancer ECM. Importantly, immune function relies heavily on the structure, physics and composition of the ECM, indicating that cancer ECM and immunity are mechanistically inseparable. In this review we highlight mechanisms by which the ECM shapes tumour immunity, identifying potential therapeutic targets within the ECM. These data indicate that to fully realise the potential of cancer immunotherapy, the cancer ECM requires simultaneous consideration.",

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AB - The extracellular matrix (ECM) plays an increasingly recognised role in the development and progression of cancer. Whilst significant progress has been made in targeting aspects of the tumour microenvironment such as tumour immunity and angiogenesis, there are no therapies that address the cancer ECM. Importantly, immune function relies heavily on the structure, physics and composition of the ECM, indicating that cancer ECM and immunity are mechanistically inseparable. In this review we highlight mechanisms by which the ECM shapes tumour immunity, identifying potential therapeutic targets within the ECM. These data indicate that to fully realise the potential of cancer immunotherapy, the cancer ECM requires simultaneous consideration.

KW - Cancer

KW - Collagen

KW - Extracellular matrix

KW - Fibronectin

KW - Immune

KW - Immune checkpoint

KW - Immunity

KW - Metastasis

KW - Microenvironment

KW - Therapy

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Cancer extracellular matrix proteins regulate tumour immunity

Abstract

Keywords

ASJC Scopus subject areas

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