Abstract
The generation and maintenance of immune responses are controlled by both co-stimulatory and co-inhibitory signalling through T cell co-receptors, many of which belong to the immunoglobulin-like superfamily or the tumour necrosis factor receptor superfamily. Agonistic or antagonistic monoclonal antibodies targeting these co-receptors have the potential to enhance immunity. Furthermore, their activity on the immunosuppressive regulatory T cell populations which are prevalent within many tumours provides an additional rationale for their use as anti-cancer therapies. This review summarizes the interactions between cancer and the immune system, highlighting the ways in which these new classes of immunostimulatory antibodies might enhance anti-tumour immunity and summarizing early clinical experience with their use.
Original language | English (US) |
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Pages (from-to) | 9-19 |
Number of pages | 11 |
Journal | Clinical and Experimental Immunology |
Volume | 157 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2009 |
Externally published | Yes |
Keywords
- CTLA-4
- Cancer immunotherapy
- Co-inhibition
- Co-stimulation
- Regulatory T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology