Cancer immunotherapy targeting the telomerase reverse transcriptase.

Long Fei Huo; Janice Ws Tang; Jun Jian Huang; Pei Tang Huang; Cui Fen Huang; Hsiang Fu Kung; Marie C. Lin

Cancer immunotherapy targeting the telomerase reverse transcriptase.

Long Fei Huo, Janice Ws Tang, Jun Jian Huang, Pei Tang Huang, Cui Fen Huang, Hsiang Fu Kung, Marie C. Lin

Research output: Contribution to journal › Review article › peer-review

Abstract

The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Cellular & molecular immunology
Volume	3
Issue number	1
State	Published - Feb 2006
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Cite this

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title = "Cancer immunotherapy targeting the telomerase reverse transcriptase.",

abstract = "The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.",

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AU - Huo, Long Fei

AU - Tang, Janice Ws

AU - Huang, Jun Jian

AU - Huang, Pei Tang

AU - Huang, Cui Fen

AU - Kung, Hsiang Fu

AU - Lin, Marie C.

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N2 - The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.

AB - The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.

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Cancer immunotherapy targeting the telomerase reverse transcriptase.

Abstract

ASJC Scopus subject areas

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