CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER

John J. Mulvihill; Roger R. Connelly; Donald F. Austin; Joeann W. Cook; Frederick F. Holmes; Margot R. Krauss; J. Wister Meigs; Sandra C. Steinhorn; M. Jane Teta; Max H. Myers; Julianne Byrne; Kay Bragg; Dawn D. Hassinger; Grace F. Holmes; Howard B. Latourette; M. Darlene Naughton; Louise C. Strong; Peter J. Weyer

doi:10.1016/S0140-6736(87)91012-9

CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER

John J. Mulvihill, Roger R. Connelly, Donald F. Austin, Joeann W. Cook, Frederick F. Holmes, Margot R. Krauss, J. Wister Meigs, Sandra C. Steinhorn, M. Jane Teta, Max H. Myers, Julianne Byrne, Kay Bragg, Dawn D. Hassinger, Grace F. Holmes, Howard B. Latourette, M. Darlene Naughton, Louise C. Strong, Peter J. Weyer

Genetics

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Abstract

A multicentre retrospective cohort study of long-term survivors of childhood and adolescent cancer identified 7 cases of cancer among 2308 offspring (0·30%) of 2283 case-survivors and 11 cases among 4719 offspring (0·23%) of 3604 controls. Overall, the observed numbers of cases were not significantly different from those expected in the general population. Among offspring of case-survivors observed for the first 5 years of life, the group with the most person-years of follow-up, 5 cancers were reported (3 confirmed), compared with 1·7 expected, a significant excess due mostly to boys whose mothers survived cancer. Some offspring with cancer had known single-gene traits; others resembled previously recognised patterns of family cancer. The remainder may represent chance occurrences or new cancer family syndromes, such as an association with malignant melanoma. The study had an overall 79% power to detect a 3-fold excess of cancer among offspring of case-survivors, but no excess was observed. The number person-years of follow-up in the second decade of life, when most cases of cancer developed, was small.

Original language	English (US)
Pages (from-to)	813-817
Number of pages	5
Journal	The Lancet
Volume	330
Issue number	8563
DOIs	https://doi.org/10.1016/S0140-6736(87)91012-9
State	Published - Oct 10 1987

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(87)91012-9

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Mulvihill, J. J., Connelly, R. R., Austin, D. F., Cook, J. W., Holmes, F. F., Krauss, M. R., Meigs, J. W., Steinhorn, S. C., Teta, M. J., Myers, M. H., Byrne, J., Bragg, K., Hassinger, D. D., Holmes, G. F., Latourette, H. B., Naughton, M. D., Strong, L. C., & Weyer, P. J. (1987). CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER. The Lancet, 330(8563), 813-817. https://doi.org/10.1016/S0140-6736(87)91012-9

Mulvihill, JJ, Connelly, RR, Austin, DF, Cook, JW, Holmes, FF, Krauss, MR, Meigs, JW, Steinhorn, SC, Teta, MJ, Myers, MH, Byrne, J, Bragg, K, Hassinger, DD, Holmes, GF, Latourette, HB, Naughton, MD, Strong, LC & Weyer, PJ 1987, 'CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER', The Lancet, vol. 330, no. 8563, pp. 813-817. https://doi.org/10.1016/S0140-6736(87)91012-9

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title = "CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER",

abstract = "A multicentre retrospective cohort study of long-term survivors of childhood and adolescent cancer identified 7 cases of cancer among 2308 offspring (0·30%) of 2283 case-survivors and 11 cases among 4719 offspring (0·23%) of 3604 controls. Overall, the observed numbers of cases were not significantly different from those expected in the general population. Among offspring of case-survivors observed for the first 5 years of life, the group with the most person-years of follow-up, 5 cancers were reported (3 confirmed), compared with 1·7 expected, a significant excess due mostly to boys whose mothers survived cancer. Some offspring with cancer had known single-gene traits; others resembled previously recognised patterns of family cancer. The remainder may represent chance occurrences or new cancer family syndromes, such as an association with malignant melanoma. The study had an overall 79% power to detect a 3-fold excess of cancer among offspring of case-survivors, but no excess was observed. The number person-years of follow-up in the second decade of life, when most cases of cancer developed, was small.",

author = "Mulvihill, {John J.} and Connelly, {Roger R.} and Austin, {Donald F.} and Cook, {Joeann W.} and Holmes, {Frederick F.} and Krauss, {Margot R.} and Meigs, {J. Wister} and Steinhorn, {Sandra C.} and Teta, {M. Jane} and Myers, {Max H.} and Julianne Byrne and Kay Bragg and Hassinger, {Dawn D.} and Holmes, {Grace F.} and Latourette, {Howard B.} and Naughton, {M. Darlene} and Strong, {Louise C.} and Weyer, {Peter J.}",

note = "Funding Information: Dr Richard B. Everson raised the possibility of this study in 1974. We are indebted to reviewing consultants (Dr C. White, Dr W. J. Schull, and Dr M. Nesbit), a large field staff, and clerical and data processing staff, in particular Ms S. Twomey and Mr D. Drummond, ORI, Inc, and Ms M. McAdams and Mrs T. Swenson, IMS, Inc. This work was supported in part by National Cancer Institute contracts N01-CP-01000, 01002, 01003, 01035, 01036, 11011, 11025, 53522, and CN-45186.",

year = "1987",

month = oct,

day = "10",

doi = "10.1016/S0140-6736(87)91012-9",

language = "English (US)",

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pages = "813--817",

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T1 - CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER

AU - Mulvihill, John J.

AU - Connelly, Roger R.

AU - Austin, Donald F.

AU - Cook, Joeann W.

AU - Holmes, Frederick F.

AU - Krauss, Margot R.

AU - Meigs, J. Wister

AU - Steinhorn, Sandra C.

AU - Teta, M. Jane

AU - Myers, Max H.

AU - Byrne, Julianne

AU - Bragg, Kay

AU - Hassinger, Dawn D.

AU - Holmes, Grace F.

AU - Latourette, Howard B.

AU - Naughton, M. Darlene

AU - Strong, Louise C.

AU - Weyer, Peter J.

N1 - Funding Information: Dr Richard B. Everson raised the possibility of this study in 1974. We are indebted to reviewing consultants (Dr C. White, Dr W. J. Schull, and Dr M. Nesbit), a large field staff, and clerical and data processing staff, in particular Ms S. Twomey and Mr D. Drummond, ORI, Inc, and Ms M. McAdams and Mrs T. Swenson, IMS, Inc. This work was supported in part by National Cancer Institute contracts N01-CP-01000, 01002, 01003, 01035, 01036, 11011, 11025, 53522, and CN-45186.

PY - 1987/10/10

Y1 - 1987/10/10

N2 - A multicentre retrospective cohort study of long-term survivors of childhood and adolescent cancer identified 7 cases of cancer among 2308 offspring (0·30%) of 2283 case-survivors and 11 cases among 4719 offspring (0·23%) of 3604 controls. Overall, the observed numbers of cases were not significantly different from those expected in the general population. Among offspring of case-survivors observed for the first 5 years of life, the group with the most person-years of follow-up, 5 cancers were reported (3 confirmed), compared with 1·7 expected, a significant excess due mostly to boys whose mothers survived cancer. Some offspring with cancer had known single-gene traits; others resembled previously recognised patterns of family cancer. The remainder may represent chance occurrences or new cancer family syndromes, such as an association with malignant melanoma. The study had an overall 79% power to detect a 3-fold excess of cancer among offspring of case-survivors, but no excess was observed. The number person-years of follow-up in the second decade of life, when most cases of cancer developed, was small.

AB - A multicentre retrospective cohort study of long-term survivors of childhood and adolescent cancer identified 7 cases of cancer among 2308 offspring (0·30%) of 2283 case-survivors and 11 cases among 4719 offspring (0·23%) of 3604 controls. Overall, the observed numbers of cases were not significantly different from those expected in the general population. Among offspring of case-survivors observed for the first 5 years of life, the group with the most person-years of follow-up, 5 cancers were reported (3 confirmed), compared with 1·7 expected, a significant excess due mostly to boys whose mothers survived cancer. Some offspring with cancer had known single-gene traits; others resembled previously recognised patterns of family cancer. The remainder may represent chance occurrences or new cancer family syndromes, such as an association with malignant melanoma. The study had an overall 79% power to detect a 3-fold excess of cancer among offspring of case-survivors, but no excess was observed. The number person-years of follow-up in the second decade of life, when most cases of cancer developed, was small.

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ER -

CANCER IN OFFSPRING OF LONG-TERM SURVIVORS OF CHILDHOOD AND ADOLESCENT CANCER

Abstract

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