TY - JOUR
T1 - Cancer metabolic reprogramming
T2 - importance, main features, and potentials for precise targeted anti-cancer therapies
AU - Phan, Liem Minh
AU - Yeung, Sai Ching Jim
AU - Lee, Mong Hong
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
AB - Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients.
KW - Cell cycle
KW - Energy metabolism
KW - Glutaminolysis
KW - Glycolysis
KW - Mitochondria biogenesis
UR - http://www.scopus.com/inward/record.url?scp=84897935083&partnerID=8YFLogxK
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U2 - 10.7497/j.issn.2095-3941.2014.01.001
DO - 10.7497/j.issn.2095-3941.2014.01.001
M3 - Review article
C2 - 24738035
AN - SCOPUS:84897935083
SN - 2095-3941
VL - 11
SP - 1
EP - 19
JO - Cancer Biology and Medicine
JF - Cancer Biology and Medicine
IS - 1
ER -