TY - JOUR
T1 - Cancer-on-chip models for metastasis
T2 - importance of the tumor microenvironment
AU - Jouybar, Mohammad
AU - de Winde, Charlotte M.
AU - Wolf, Katarina
AU - Friedl, Peter
AU - Mebius, Reina E.
AU - den Toonder, Jaap M.J.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2024/4
Y1 - 2024/4
N2 - Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.
AB - Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for 3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC models are therefore increasingly used to systematically study effects of the TME on the various steps in cancer metastasis. Moreover, CoC models have great potential for developing novel cancer therapies and for predicting patient-specific response to cancer treatments. We review recent developments in CoC models, focusing on three main TME components: (i) the anisotropic extracellular matrix (ECM) architectures, (ii) the vasculature, and (iii) the immune system. We aim to provide guidance to biologists to choose the best CoC approach for addressing questions about the role of the TME in metastasis, and to inspire engineers to develop novel CoC technologies.
KW - Cancer-on-chip
KW - extracellular matrix
KW - immune system
KW - tumor microenvironment
KW - vasculature
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U2 - 10.1016/j.tibtech.2023.10.001
DO - 10.1016/j.tibtech.2023.10.001
M3 - Review article
C2 - 37914546
AN - SCOPUS:85175263255
SN - 0167-7799
VL - 42
SP - 431
EP - 448
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 4
ER -