Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

Mark E. Dudley; John R. Wunderlich; Paul F. Robbins; James C. Yang; Patrick Hwu; Douglas J. Schwartzentruber; Suzanne L. Topalian; Richard Sherry; Nicholas P. Restifo; Amy M. Hubicki; Michael R. Robinson; Mark Raffeld; Paul Duray; Claudia A. Seipp; Linda Rogers-Freezer; Kathleen E. Morton; Sharon A. Mavroukakis; Donald E. White; Steven A. Rosenberg

doi:10.1126/science.1076514

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

Mark E. Dudley, John R. Wunderlich, Paul F. Robbins, James C. Yang, Patrick Hwu, Douglas J. Schwartzentruber, Suzanne L. Topalian, Richard Sherry, Nicholas P. Restifo, Amy M. Hubicki, Michael R. Robinson, Mark Raffeld, Paul Duray, Claudia A. Seipp, Linda Rogers-Freezer, Kathleen E. Morton, Sharon A. Mavroukakis, Donald E. White, Steven A. Rosenberg

Graduate School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

2473 Scopus citations

Abstract

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases.

Original language	English (US)
Pages (from-to)	850-854
Number of pages	5
Journal	Science
Volume	298
Issue number	5594
DOIs	https://doi.org/10.1126/science.1076514
State	Published - Oct 25 2002

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Dudley, M. E., Wunderlich, J. R., Robbins, P. F., Yang, J. C., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Sherry, R., Restifo, N. P., Hubicki, A. M., Robinson, M. R., Raffeld, M., Duray, P., Seipp, C. A., Rogers-Freezer, L., Morton, K. E., Mavroukakis, S. A., White, D. E., & Rosenberg, S. A. (2002). Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science, 298(5594), 850-854. https://doi.org/10.1126/science.1076514

Dudley, ME, Wunderlich, JR, Robbins, PF, Yang, JC, Hwu, P, Schwartzentruber, DJ, Topalian, SL, Sherry, R, Restifo, NP, Hubicki, AM, Robinson, MR, Raffeld, M, Duray, P, Seipp, CA, Rogers-Freezer, L, Morton, KE, Mavroukakis, SA, White, DE & Rosenberg, SA 2002, 'Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes', Science, vol. 298, no. 5594, pp. 850-854. https://doi.org/10.1126/science.1076514

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title = "Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes",

abstract = "We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases.",

author = "Dudley, {Mark E.} and Wunderlich, {John R.} and Robbins, {Paul F.} and Yang, {James C.} and Patrick Hwu and Schwartzentruber, {Douglas J.} and Topalian, {Suzanne L.} and Richard Sherry and Restifo, {Nicholas P.} and Hubicki, {Amy M.} and Robinson, {Michael R.} and Mark Raffeld and Paul Duray and Seipp, {Claudia A.} and Linda Rogers-Freezer and Morton, {Kathleen E.} and Mavroukakis, {Sharon A.} and White, {Donald E.} and Rosenberg, {Steven A.}",

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AU - Schwartzentruber, Douglas J.

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AU - Sherry, Richard

AU - Restifo, Nicholas P.

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AU - Raffeld, Mark

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Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

Abstract

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