TY - JOUR
T1 - Cancer-related Fatigue in Lung Cancer
T2 - A Research Agenda An Official American Thoracic Society Research Statement
AU - American Thoracic Society Assembly on Thoracic Oncology
AU - Bade, Brett C.
AU - Faiz, Saadia A.
AU - Ha, Duc M.
AU - Tan, Miranda
AU - Barton-Burke, Margaret
AU - Cheville, Andrea L.
AU - Escalante, Carmen P.
AU - Gozal, David
AU - Granger, Catherine L.
AU - Presley, Carolyn J.
AU - Smith, Sheree M.
AU - Chamberlaine, Dawn M.
AU - Long, Jason M.
AU - Malone, Daniel J.
AU - Pirl, William F.
AU - Robinson, Halley L.
AU - Yasufuku, Kazuhiro
AU - Rivera, M. Patricia
N1 - Publisher Copyright:
Copyright © 2023 by the American Thoracic Society.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Background: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despit more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research question to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel’s initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors.
AB - Background: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despit more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research question to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel’s initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors.
KW - cancer-related fatigue
KW - exercise training
KW - lung cancer
KW - physical activity
KW - rehabilitation
KW - sleep disorder
KW - sleep disturbance
KW - survivorship
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U2 - 10.1164/rccm.202210-1963ST
DO - 10.1164/rccm.202210-1963ST
M3 - Article
C2 - 36856560
AN - SCOPUS:85149427983
SN - 1073-449X
VL - 207
SP - E6-E28
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 5
ER -