TY - JOUR
T1 - Cancer stem cell definitions and terminology
T2 - The devil is in the details
AU - Valent, Peter
AU - Bonnet, Dominique
AU - De Maria, Ruggero
AU - Lapidot, Tsvee
AU - Copland, Mhairi
AU - Melo, Junia V.
AU - Chomienne, Christine
AU - Ishikawa, Fumihiko
AU - Schuringa, Jan Jacob
AU - Stassi, Giorgio
AU - Huntly, Brian
AU - Herrmann, Harald
AU - Soulier, Jean
AU - Roesch, Alexander
AU - Schuurhuis, Gerrit Jan
AU - Wöhrer, Stefan
AU - Arock, Michel
AU - Zuber, Johannes
AU - Cerny-Reiterer, Sabine
AU - Johnsen, Hans E.
AU - Andreeff, Michael
AU - Eaves, Connie
N1 - Funding Information:
supported by a Cancer Stem Cell Grant of the Medical University of Vienna, Austria. The authors would like to thank S. Sonnleitner and K. Krassel for their helpful technical support. H.E.J. was supported by the EU 6th FP to MSCNET (LSHC-CT-2006-037602). M.C. is supported by a Fellowship from the Scottish Funding Council (SCD/04) and J.V.M. by the NIHR Biomedical Research Centre Funding Scheme, UK.
PY - 2012/11
Y1 - 2012/11
N2 - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.
AB - The cancer stem cell (CSC) concept has important therapeutic implications, but its investigation has been hampered both by a lack of consistency in the terms used for these cells and by how they are defined. Evidence of their heterogeneous origins, frequencies and their genomic, as well as their phenotypic and functional, properties has added to the confusion and has fuelled new ideas and controversies. Participants in The Year 2011 Working Conference on CSCs met to review these issues and to propose a conceptual and practical framework for CSC terminology. More precise reporting of the parameters that are used to identify CSCs and to attribute responses to them is also recommended as key to accelerating an understanding of their biology and developing more effective methods for their eradication in patients.
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U2 - 10.1038/nrc3368
DO - 10.1038/nrc3368
M3 - Review article
C2 - 23051844
AN - SCOPUS:84867878045
SN - 1474-175X
VL - 12
SP - 767
EP - 775
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 11
ER -