Cancer stem cell radioresistance and enrichment: Where frontline radiation therapy may fail in lung and esophageal cancers

Giang Huong Nguyen; Mandi M. Murph; Joe Y. Chang

doi:10.3390/cancers3011232

Cancer stem cell radioresistance and enrichment: Where frontline radiation therapy may fail in lung and esophageal cancers

Giang Huong Nguyen, Mandi M. Murph, Joe Y. Chang

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.

Original language	English (US)
Pages (from-to)	1232-1252
Number of pages	21
Journal	Cancers
Volume	3
Issue number	1
DOIs	https://doi.org/10.3390/cancers3011232
State	Published - Mar 2011

Keywords

Cancer stem cells
Esophageal cancer
Lung cancer
Radiation therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers3011232

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abstract = "Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.",

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AB - Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.

KW - Cancer stem cells

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KW - Lung cancer

KW - Radiation therapy

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Cancer stem cell radioresistance and enrichment: Where frontline radiation therapy may fail in lung and esophageal cancers

Abstract

Keywords

ASJC Scopus subject areas

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