Abstract
Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative modeling studies that augment our understanding of stem and non-stem cancer cell interactions during tumor progression and the resulting fraction of cancer stem cells. A discussion of how these findings can be carefully evaluated in novel, integrated interdisciplinary studies is offered.
Original language | English (US) |
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Pages (from-to) | 14-23 |
Number of pages | 10 |
Journal | Integrative Biology (United Kingdom) |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry