Cancer targeting using tumor suppressor genes

Sunil Chada; Kerstin B. Menander; Dora Bocangel; Jack A. Roth; Rajagopal Ramesh

doi:10.2741/2815

Cancer targeting using tumor suppressor genes

Sunil Chada, Kerstin B. Menander, Dora Bocangel, Jack A. Roth, Rajagopal Ramesh

Thoracic & Cardiovascular Surgery

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drags that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

Original language	English (US)
Pages (from-to)	1959-1967
Number of pages	9
Journal	Frontiers in Bioscience
Volume	13
Issue number	5
DOIs	https://doi.org/10.2741/2815
State	Published - 2008

Keywords

Adenovirus
Cancer
Review
Tumor suppressor
p53

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Access to Document

10.2741/2815

Cite this

@article{b0be036bfcf54beeb650621cced46cd2,

title = "Cancer targeting using tumor suppressor genes",

abstract = "Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drags that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.",

keywords = "Adenovirus, Cancer, Review, Tumor suppressor, p53",

author = "Sunil Chada and Menander, {Kerstin B.} and Dora Bocangel and Roth, {Jack A.} and Rajagopal Ramesh",

year = "2008",

doi = "10.2741/2815",

language = "English (US)",

volume = "13",

pages = "1959--1967",

journal = "Frontiers in Bioscience",

issn = "2768-6701",

publisher = "Frontiers in Bioscience",

number = "5",

}

TY - JOUR

T1 - Cancer targeting using tumor suppressor genes

AU - Chada, Sunil

AU - Menander, Kerstin B.

AU - Bocangel, Dora

AU - Roth, Jack A.

AU - Ramesh, Rajagopal

PY - 2008

Y1 - 2008

N2 - Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drags that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

AB - Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drags that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

KW - Adenovirus

KW - Cancer

KW - Review

KW - Tumor suppressor

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=38449096987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449096987&partnerID=8YFLogxK

U2 - 10.2741/2815

DO - 10.2741/2815

M3 - Review article

C2 - 17981683

AN - SCOPUS:38449096987

SN - 2768-6701

VL - 13

SP - 1959

EP - 1967

JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

IS - 5

ER -

Cancer targeting using tumor suppressor genes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this