Cancer targeting using tumor suppressor genes

Sunil Chada, Kerstin B. Menander, Dora Bocangel, Jack A. Roth, Rajagopal Ramesh

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drags that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.

Original languageEnglish (US)
Pages (from-to)1959-1967
Number of pages9
JournalFrontiers in Bioscience
Volume13
Issue number5
DOIs
StatePublished - May 5 2008

Keywords

  • Adenovirus
  • Cancer
  • Review
  • Tumor suppressor
  • p53

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Chada, S., Menander, K. B., Bocangel, D., Roth, J. A., & Ramesh, R. (2008). Cancer targeting using tumor suppressor genes. Frontiers in Bioscience, 13(5), 1959-1967. https://doi.org/10.2741/2815