TY - JOUR
T1 - Caprylic acid and glyceryl trinitrate combination for eradication of biofilm
AU - Rosenblatt, Joel
AU - Reitzel, Ruth A.
AU - Raad, Issam
N1 - Publisher Copyright:
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - There is a growing need for biocompatible, broad-spectrum, nonantibiotic, antimicrobial treatments because of the frequent ineffectiveness of antibiotics against biofilms and the increasing incidence of antibiotic resistance. In this study, we demonstrate rapid and complete biofilm eradication in an in vitro model with synergistic combinations of glyceryl trinitrate and caprylic acid against resistant Gram-positive, Gram-negative, and fungal biofilms.
AB - There is a growing need for biocompatible, broad-spectrum, nonantibiotic, antimicrobial treatments because of the frequent ineffectiveness of antibiotics against biofilms and the increasing incidence of antibiotic resistance. In this study, we demonstrate rapid and complete biofilm eradication in an in vitro model with synergistic combinations of glyceryl trinitrate and caprylic acid against resistant Gram-positive, Gram-negative, and fungal biofilms.
UR - http://www.scopus.com/inward/record.url?scp=84923240005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923240005&partnerID=8YFLogxK
U2 - 10.1128/AAC.04561-14
DO - 10.1128/AAC.04561-14
M3 - Article
C2 - 25534725
AN - SCOPUS:84923240005
SN - 0066-4804
VL - 59
SP - 1786
EP - 1788
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 3
ER -