Abstract
Meropenem and imipenem/cilastatin, currently the only available carbapenem agents in Europe and the United States, are characterised by a broad spectrum of antimicrobial activity and stability to β-lactamase-mediated resistance mechanisms. A guide to the use of carbapenems in clinical practice is presented; the role of carbapenems in the treatment of several types of serious bacterial infection and an up-to-date account of their clinical efficacy and safety profiles are discussed. The good clinical efficacy and favourable safety profiles of the carbapenems make them valuable as initial empirical therapy in the treatment of ventilator-associated pneumonia, sepsis of unknown origin, post-operative peritonitis, paediatric meningitis, and febrile neutropenia. However, to maintain superior efficacy, the carbapenems should be used appropriately for definitive therapy. Copyright (C) 1999 Elsevier Science B.V./International Society of Chemotherapy.
Original language | English (US) |
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Pages (from-to) | 93-100 |
Number of pages | 8 |
Journal | International Journal of Antimicrobial Agents |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1999 |
Keywords
- Bacterial infection
- Carbapenem
- β-Lactamase
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)