TY - JOUR
T1 - Carbon Fiber-Reinforced Polyetheretherketone Spinal Implants for Treatment of Spinal Tumors
T2 - Perceived Advantages and Limitations
AU - Alvarez-Breckenridge, Christopher
AU - de Almeida, Romulo
AU - Haider, Ali
AU - Muir, Matthew
AU - Bird, Justin
AU - North, Robert
AU - Rhines, Laurence
AU - Tatsui, Claudio
N1 - Publisher Copyright:
© 2023 Alvarez-Breckenridge C, et al.
PY - 2023/3
Y1 - 2023/3
N2 - Purpose: Carbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its use in the management of spinal tumors has been reported, however the perceived advantages related to improved imaging quality, radiation treatment planning, and detection of tumor recurrence have not been fully assessed. Methods: We performed a retrospective review of medical records amongst oncologic patients treated at MD Anderson Cancer Center with CFRP implants. Histology, tumor loca-tion, construct features, time of follow-up, adjuvant radiation, recurrences, overall survival, and hardware-related complications were recorded. Results: Sixty-nine consecutive patients were assessed (22 primary tumors, 47 metastases) and the median time for follow-up was 5.4 months. Amongst the cohort, a total of 491 CFRP pedicle screws were implanted. Hardware complications were observed in 5 cases (7. 04%). Adjuvant radiation was completed in 8 patients with primary tumors and 29 patients with spinal metastases. A total of 28 patients (40. 5%) from the combined primary and metastatic cohorts experienced systemic disease progression, with 12 patients (17. 3%) demonstrating local recurrences. Amongst primary and metastatic tumors, overall survival (p = 0.363) and rate of local recurrence (p = 0. 112) were similar. Conclusion: This largest series of CFRP implants demonstrates safe and effective spinal stabilization for patients with both primary and metastatic tumors. Enhanced postoperative imaging led to minimal imaging artifacts which facilitated postoperative radiation planning and the ability to detect local recurrence.
AB - Purpose: Carbon-fiber reinforced polyetheretherketone (CFRP)-based spinal implants are an alternative to titanium, offering less image artifact as their metallic counterparts while maintaining similar biomechanical and biocompatibility properties. Its use in the management of spinal tumors has been reported, however the perceived advantages related to improved imaging quality, radiation treatment planning, and detection of tumor recurrence have not been fully assessed. Methods: We performed a retrospective review of medical records amongst oncologic patients treated at MD Anderson Cancer Center with CFRP implants. Histology, tumor loca-tion, construct features, time of follow-up, adjuvant radiation, recurrences, overall survival, and hardware-related complications were recorded. Results: Sixty-nine consecutive patients were assessed (22 primary tumors, 47 metastases) and the median time for follow-up was 5.4 months. Amongst the cohort, a total of 491 CFRP pedicle screws were implanted. Hardware complications were observed in 5 cases (7. 04%). Adjuvant radiation was completed in 8 patients with primary tumors and 29 patients with spinal metastases. A total of 28 patients (40. 5%) from the combined primary and metastatic cohorts experienced systemic disease progression, with 12 patients (17. 3%) demonstrating local recurrences. Amongst primary and metastatic tumors, overall survival (p = 0.363) and rate of local recurrence (p = 0. 112) were similar. Conclusion: This largest series of CFRP implants demonstrates safe and effective spinal stabilization for patients with both primary and metastatic tumors. Enhanced postoperative imaging led to minimal imaging artifacts which facilitated postoperative radiation planning and the ability to detect local recurrence.
KW - Carbon fiber
KW - Radiation
KW - Spinal oncology
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U2 - 10.14245/ns.2244920.460
DO - 10.14245/ns.2244920.460
M3 - Article
C2 - 37016879
AN - SCOPUS:85153534094
SN - 2586-6583
VL - 20
SP - 317
EP - 326
JO - Neurospine
JF - Neurospine
IS - 1
ER -