Carcinogenesis: Balance between apoptosis and survival pathways

Dean G. Tang; James P. Kehrer

doi:10.1007/978-1-59745-200-7_4

Carcinogenesis: Balance between apoptosis and survival pathways

Dean G. Tang, James P. Kehrer

Epigenetics & Molecular Carcinogenesis

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Numerous molecules and pathways have been identified that control various aspects of apoptosis and survival signaling. A dynamic balance between these opposing activities is required to finetune biological systems under both normal and stressed conditions. In this chapter, pathways leading to apoptosis are briefly summarized. This is followed by a discussion of various survival pathways that are activated by both prosurvival and proapoptotic stimuli. Finally, a model depicting the simultaneous engagement of both pro-survival and pro-death pathways by stress signals is presented.

Original language	English (US)
Title of host publication	Apoptosis, Cell Signaling, and Human Diseases
Publisher	Humana Press
Pages	97-118
Number of pages	22
Volume	1
ISBN (Print)	1588296776, 9781588296771
DOIs	https://doi.org/10.1007/978-1-59745-200-7_4
State	Published - 2007

Keywords

Apoptosis
FOXO3a
NF-κB
lipocalin
reactive oxygen species (ROS)
stress
survival

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-59745-200-7_4

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AU - Kehrer, James P.

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AB - Numerous molecules and pathways have been identified that control various aspects of apoptosis and survival signaling. A dynamic balance between these opposing activities is required to finetune biological systems under both normal and stressed conditions. In this chapter, pathways leading to apoptosis are briefly summarized. This is followed by a discussion of various survival pathways that are activated by both prosurvival and proapoptotic stimuli. Finally, a model depicting the simultaneous engagement of both pro-survival and pro-death pathways by stress signals is presented.

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KW - NF-κB

KW - lipocalin

KW - reactive oxygen species (ROS)

KW - stress

KW - survival

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BT - Apoptosis, Cell Signaling, and Human Diseases

PB - Humana Press

ER -

Carcinogenesis: Balance between apoptosis and survival pathways

Abstract

Keywords

ASJC Scopus subject areas

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