Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

Tetsuya Takahashi; Tetsuro Shishido; Daisuke Kinoshita; Ken Watanabe; Taku Toshima; Takayuki Sugai; Taro Narumi; Yoichiro Otaki; Harutoshi Tamura; Satoshi Nishiyama; Takanori Arimoto; Hiroki Takahashi; Takuya Miyamoto; Tetsu Watanabe; Chang Hoon Woo; Jun ichi Abe; Yasuchika Takeishi; Isao Kubota; Masafumi Watanabe

doi:10.1016/j.jacbts.2018.11.011

Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

Tetsuya Takahashi, Tetsuro Shishido, Daisuke Kinoshita, Ken Watanabe, Taku Toshima, Takayuki Sugai, Taro Narumi, Yoichiro Otaki, Harutoshi Tamura, Satoshi Nishiyama, Takanori Arimoto, Hiroki Takahashi, Takuya Miyamoto, Tetsu Watanabe, Chang Hoon Woo, Jun ichi Abe, Yasuchika Takeishi, Isao Kubota, Masafumi Watanabe

Cardiology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac-specific HMGB1 overexpression transgenic mice after angiotensin II stimulation as compared with wild-type mice. In vitro, inhibition of HMGB1 increased phosphorylation of extracellular signal-related kinase 1/2 and nuclear factor kappa B, which was rescued by DDR inhibitor treatment. DDR inhibitor treatment provided a cardioprotective effect on angiotensin II–induced cardiac remodeling in mice.

Original language	English (US)
Pages (from-to)	234-247
Number of pages	14
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2018.11.011
State	Published - Apr 2019

Keywords

DNA damage response
HMGB1
pathological cardiac hypertrophy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2018.11.011

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Takahashi, T., Shishido, T., Kinoshita, D., Watanabe, K., Toshima, T., Sugai, T., Narumi, T., Otaki, Y., Tamura, H., Nishiyama, S., Arimoto, T., Takahashi, H., Miyamoto, T., Watanabe, T., Woo, C. H., Abe, J. I., Takeishi, Y., Kubota, I., & Watanabe, M. (2019). Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response. JACC: Basic to Translational Science, 4(2), 234-247. https://doi.org/10.1016/j.jacbts.2018.11.011

Takahashi, T, Shishido, T, Kinoshita, D, Watanabe, K, Toshima, T, Sugai, T, Narumi, T, Otaki, Y, Tamura, H, Nishiyama, S, Arimoto, T, Takahashi, H, Miyamoto, T, Watanabe, T, Woo, CH, Abe, JI, Takeishi, Y, Kubota, I & Watanabe, M 2019, 'Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response', JACC: Basic to Translational Science, vol. 4, no. 2, pp. 234-247. https://doi.org/10.1016/j.jacbts.2018.11.011

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abstract = "High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac-specific HMGB1 overexpression transgenic mice after angiotensin II stimulation as compared with wild-type mice. In vitro, inhibition of HMGB1 increased phosphorylation of extracellular signal-related kinase 1/2 and nuclear factor kappa B, which was rescued by DDR inhibitor treatment. DDR inhibitor treatment provided a cardioprotective effect on angiotensin II–induced cardiac remodeling in mice.",

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author = "Tetsuya Takahashi and Tetsuro Shishido and Daisuke Kinoshita and Ken Watanabe and Taku Toshima and Takayuki Sugai and Taro Narumi and Yoichiro Otaki and Harutoshi Tamura and Satoshi Nishiyama and Takanori Arimoto and Hiroki Takahashi and Takuya Miyamoto and Tetsu Watanabe and Woo, {Chang Hoon} and Abe, {Jun ichi} and Yasuchika Takeishi and Isao Kubota and Masafumi Watanabe",

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AU - Shishido, Tetsuro

AU - Kinoshita, Daisuke

AU - Watanabe, Ken

AU - Toshima, Taku

AU - Sugai, Takayuki

AU - Narumi, Taro

AU - Otaki, Yoichiro

AU - Tamura, Harutoshi

AU - Nishiyama, Satoshi

AU - Arimoto, Takanori

AU - Takahashi, Hiroki

AU - Miyamoto, Takuya

AU - Watanabe, Tetsu

AU - Woo, Chang Hoon

AU - Abe, Jun ichi

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AU - Kubota, Isao

AU - Watanabe, Masafumi

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AB - High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. Decreased nuclear HMGB1 expression and increased DNA damage response (DDR) were observed in human failing hearts. DNA damage and DDR as well as cardiac remodeling were suppressed in cardiac-specific HMGB1 overexpression transgenic mice after angiotensin II stimulation as compared with wild-type mice. In vitro, inhibition of HMGB1 increased phosphorylation of extracellular signal-related kinase 1/2 and nuclear factor kappa B, which was rescued by DDR inhibitor treatment. DDR inhibitor treatment provided a cardioprotective effect on angiotensin II–induced cardiac remodeling in mice.

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Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

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Keywords

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