TY - JOUR
T1 - Case-control assessment of diet and lung cancer risk in African Americans and Mexican Americans
AU - Pillow, Patricia C.
AU - Hursting, Stephen D.
AU - Duphorne, Cherie M.
AU - Jiang, Hong
AU - Honn, Susan E.
AU - Chang, Shine
AU - Spitz, Margaret R.
N1 - Funding Information:
The authors thank the Veterans Administration, the Harris County Hospital District, the City of Houston Department of Health and Human Services, and the YMCA (Houston, TX) and Santa Rosa Hospital, the Baptist Memorial Hospital System, and the San Antonio Senior Centers (San Antonio, TX) for support of this study. The authors also thank Betty Henry for interviewer training and questionnaire review, Mary Harris for steadfast data entry, and Dr. Maureen Goode (Dept. of Scientific Publications, The University of Texas M. D. Anderson Cancer Center) for helpful comments. This work was supported by National Cancer Institute Grant CA-55769. Authors Pillow and Hursting contributed equally to this manuscript. In addition, S. D. Hursting is supported in part by National Cancer Institute Core Grant P30-CA-16672 (to M. D. Anderson Cancer Center). Address reprint requests to Stephen D. Hursting, Ph.D., M.P.H., The University of Texas M. D. Anderson Cancer Center, Dept. of Epidemiology, Box 189, 1515 Holcombe Blvd., Houston, TX 77030-4095.
PY - 1997
Y1 - 1997
N2 - In this case-control study we determined whether dietary differences underlie some of the ethnic and sex differences in US lung cancer rates. We examined the relationship between diet and lung cancer development in 137 lung cancer cases (93 African Americans and 44 Mexican Americans) and 187 controls (78 African Americans and 109 Mexican Americans). Cases reported a higher daily mean total fat intake (p < 0.001), whereas controls had a higher daily mean intake of dietary fiber (p < 0.001) and fruits (p = 0.02). Ethnic differences in diet were also observed: Mexican Americans consumed less total fat (p < 0.02) and more fiber (p < 0.001) and vegetables (p = 0.08) than African Americans. Additionally, men consumed more total fat (p = 0.08) and less fiber (p = 0.001), fruits (p < 0.001), and vegetables (p = 0.002) than women. Multivariable analysis, after adjustment for the effects of pack- years of smoking, age, total energy intake, sex, and ethnicity, demonstrated a positive association between high total fat consumption and lung cancer risk (p < 0.01) and an inverse association between high fruit consumption and lung cancer risk (p = 0.05). In conclusion, our findings support the hypothesis that diet, particularly high fat consumption and low fruit and vegetable consumption, contributes (independent of cigarette smoking) to the excess lung cancer risk in African-American men, who have the highest lung cancer rates in the United States.
AB - In this case-control study we determined whether dietary differences underlie some of the ethnic and sex differences in US lung cancer rates. We examined the relationship between diet and lung cancer development in 137 lung cancer cases (93 African Americans and 44 Mexican Americans) and 187 controls (78 African Americans and 109 Mexican Americans). Cases reported a higher daily mean total fat intake (p < 0.001), whereas controls had a higher daily mean intake of dietary fiber (p < 0.001) and fruits (p = 0.02). Ethnic differences in diet were also observed: Mexican Americans consumed less total fat (p < 0.02) and more fiber (p < 0.001) and vegetables (p = 0.08) than African Americans. Additionally, men consumed more total fat (p = 0.08) and less fiber (p = 0.001), fruits (p < 0.001), and vegetables (p = 0.002) than women. Multivariable analysis, after adjustment for the effects of pack- years of smoking, age, total energy intake, sex, and ethnicity, demonstrated a positive association between high total fat consumption and lung cancer risk (p < 0.01) and an inverse association between high fruit consumption and lung cancer risk (p = 0.05). In conclusion, our findings support the hypothesis that diet, particularly high fat consumption and low fruit and vegetable consumption, contributes (independent of cigarette smoking) to the excess lung cancer risk in African-American men, who have the highest lung cancer rates in the United States.
UR - http://www.scopus.com/inward/record.url?scp=0031459492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031459492&partnerID=8YFLogxK
U2 - 10.1080/01635589709514620
DO - 10.1080/01635589709514620
M3 - Article
C2 - 9427982
AN - SCOPUS:0031459492
SN - 0163-5581
VL - 29
SP - 169
EP - 173
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 2
ER -