TY - JOUR
T1 - Case-control study of the risk factors for eclampsia
AU - Abi-said, Dima
AU - Annegers, John F.
AU - Combs-cantrell, Deborah
AU - Frankowski, Ralph F.
AU - Willmore, L. James
N1 - Funding Information:
This study was supported in part by contributions from the Texas Epilepsy Center Research Program to Dr. Willmore.
PY - 1995/8/15
Y1 - 1995/8/15
N2 - A case-control study was conducted to investigate risk factors for eclampsia. A total of 66 cases of eclampsia were ascertained from deliveries between 1977 and 1992 at two hospitals in Houston, Texas, based on the criteria defined by the American College of Obstetrics and Gynecology. Cases were matched to nonpreeclamptic controls on a 4:1 ratio on the basis of hospital and month of delivery. The ratio of eclampsia cases to number of deliveries over the study penod was 0.63 per 1,000. In a logistic regression model, risk factors for eclampsia included 1) two or fewer prenatal care visits (odds ratio (OR) = 6.10, 95% confidence interval (CO 2.26-16.41), 2) urinary tract infection (OR = 4.23, 95% Cl 1.27-14.06), 3) primigravidrty (OR = 2.87, 95% Cl 0.97-8.44), 4) obesity (OR = 2.49, 95% Cl 0.78-7.96), 5) black ethnicity (OR = 2.25, 95% Cl 0.88-5.78), 6) history of diabetes (OR = 2.07, 95% Cl 0.45-9.62), and 7) age <20 years (OR = 1.55, 95% Cl 0.47-5.10). Nulliparity was not shown to be a risk factor for eclampsia when controlled for primigravidrty, and neither were previous history of abortion or previous history of pregnancy-induced hypertension. Thus, prior pregnancy itself, independent of outcome and preeclamptic/eclamptic complications, appears to be the protective factor against eclampsia in a subsequent pregnancy.
AB - A case-control study was conducted to investigate risk factors for eclampsia. A total of 66 cases of eclampsia were ascertained from deliveries between 1977 and 1992 at two hospitals in Houston, Texas, based on the criteria defined by the American College of Obstetrics and Gynecology. Cases were matched to nonpreeclamptic controls on a 4:1 ratio on the basis of hospital and month of delivery. The ratio of eclampsia cases to number of deliveries over the study penod was 0.63 per 1,000. In a logistic regression model, risk factors for eclampsia included 1) two or fewer prenatal care visits (odds ratio (OR) = 6.10, 95% confidence interval (CO 2.26-16.41), 2) urinary tract infection (OR = 4.23, 95% Cl 1.27-14.06), 3) primigravidrty (OR = 2.87, 95% Cl 0.97-8.44), 4) obesity (OR = 2.49, 95% Cl 0.78-7.96), 5) black ethnicity (OR = 2.25, 95% Cl 0.88-5.78), 6) history of diabetes (OR = 2.07, 95% Cl 0.45-9.62), and 7) age <20 years (OR = 1.55, 95% Cl 0.47-5.10). Nulliparity was not shown to be a risk factor for eclampsia when controlled for primigravidrty, and neither were previous history of abortion or previous history of pregnancy-induced hypertension. Thus, prior pregnancy itself, independent of outcome and preeclamptic/eclamptic complications, appears to be the protective factor against eclampsia in a subsequent pregnancy.
KW - Case-control studies
KW - Eclampsia
KW - Hypertension
KW - Multivariate analysis
KW - Pre-eclampsia
KW - Pregnancy toxemias
KW - Risk factors
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U2 - 10.1093/oxfordjournals.aje.a117652
DO - 10.1093/oxfordjournals.aje.a117652
M3 - Article
C2 - 7625409
AN - SCOPUS:0029148266
SN - 0002-9262
VL - 142
SP - 437
EP - 441
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 4
ER -