Case series of diffuse extraneural metastasis in H3F3A mutant high-grade gliomas: Clinical, molecular phenotype and literature review

Sana Mohiuddin, Stefania Maraka, Muhammad Usman Baig, Sumit Gupta, Tariq Muzzafar, Tibor Valyi-Nagy, Holly Lindsay, Karen Moody, Shehla Razvi, Arnold Paulino, Konstantin Slavin, Vinai Gondi, Ian McCutcheon, Wafik Zaky, Soumen Khatua

Research output: Contribution to journalArticlepeer-review

Abstract

H3K27M and H3.3G34R/V mutations have been identified in pediatric high-grade gliomas (pHGG), though extraneural metastases are rarely reported and poorly characterized. Three pHGG patients from two institutions were identified with extraneural metastasis, harboring histone mutations. Their clinical, imaging and molecular characteristics are reported here. A 17-year old female presented with supratentorial H3.3G34R-mutant glioma with metastatic osseous lesions in the spine, pelvis, bone marrow, pleural effusion and soft tissue of pelvis. Bone marrow biopsy and soft tissue of pelvis biopsy showed neoplastic cells positive for P53. A 20-year old female was diagnosed with H3F3A H3K27M–mutant thalamic glioma. She developed diffuse sclerotic osseous lesions. Biopsy of an osseous lesion was non-diagnostic. A 17-year old female presented with a H3F3A H3K27M-mutant diffuse midline glioma with diffuse spinal cord metastasis. She further developed multifocal chest lymphadenopathy, pleural effusions, and a soft tissue mass in the abdominal wall. The latter was positive for H3K27M mutation. We present the first case series of pHGG with H3F3A mutation and diffuse extraneural dissemination, describing their clinical and molecular profile.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalJournal of Clinical Neuroscience
Volume89
DOIs
StatePublished - Jul 2021

Keywords

  • Extraneural disease
  • H3.3G34R/V
  • H3K27M
  • High-grade glioma
  • Metastasis
  • Mutation profile

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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