Caspase-9 swings both ways in the apoptosome

Chu Chiao Wu, Shawn B. Bratton

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

For nearly 2 decades, investigators have debated whether cysteinyl-aspartate-specific protease 9 (caspase-9) is activated within the apoptotic protease-activating factor 1 (Apaf-1) apoptosome through proximity-induced homodimerization or through formation of a holoenzyme. Recently, we have demonstrated that caspase-9 forms (and likely transitions between) both caspase-9 homo- and Apaf-1:caspase-9 heterodimers, each of which plays unique roles in the recruitment and activation of caspase-9.

Original languageEnglish (US)
Article numbere1281865
JournalMolecular and Cellular Oncology
Volume4
Issue number2
DOIs
StatePublished - Mar 4 2017

Keywords

  • Apaf-1
  • apoptosome
  • caspase-3
  • caspase-9
  • molecular timer

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

Fingerprint Dive into the research topics of 'Caspase-9 swings both ways in the apoptosome'. Together they form a unique fingerprint.

  • Cite this