TY - JOUR
T1 - Caveolin-1 and VEGF-C promote lymph node metastasis in the absence of intratumoral lymphangiogenesis in non-small cell lung cancer
AU - Li, Minhua
AU - Chen, Honglei
AU - Diao, Luming
AU - Zhang, Yuxia
AU - Xia, Cong
AU - Yang, Fei
PY - 2010
Y1 - 2010
N2 - Aims and background. Caveolin-1 is a key component of membrane caveolae which plays an important role in cell transformation, cell migration, metastasis and angiogenesis. The mechanism of caveolin-1 and VEGF-C in lymphatic metastasis of non-small cell lung cancer (NSCLC) is still unclear. This study aimed to define the caveolin-1 and VEGF-C expression and lymph vessel density in NSCLC and look for correlations with clinicopathological features in NSCLC. Methods. Caveolin-1, VEGF-C, and D2-40 protein expression were assessed by immunohistochemistry in a tissuemicroarray constructed from70 NSCLCs and 12 normal lungs. Results. Caveolin-1 expression was detected in 31 of 70 (44.3%) NSCLCs, which was significantly lower than its expression in normal lungs (9 of 12, 75%; P = 0.049). Expression of VEGF-C was detected in 49 of 70 (70%) NSCLCs and 4 of 12 (33.3%) normal lungs (P = 0.022). Both caveolin-1 and VEGF-C expression were correlated with lymph node metastasis of NSCLC (P = 0.001; P = 0.028). Moreover, caveolin-1 expression was correlated with tumor stage, histological type, and differentiation grade (P = 0.012; P = 0.038; P = 0.002). VEGF-C expression was correlated only with histological type (P = 0.020). There was no correlation between intratumoral lymph vessel density and any clinicopathological parameters including lymph node status. Furthermore, there was no correlation between caveolin-1 expression, VEGF-C expression, and lymph vessel density. Conclusions. These findings indicated a reduction of caveolin-1 expression in NSCLC and suggested that caveolin-1 as well as VEGF-C might be involved in lymph node metastasis of NSCLC. The role of caveolin-1 in lymphaticmetastasis and intratumoral lymphangiogenesis in NSCLC needs further study. Free full text available at www. tumorionline.it.
AB - Aims and background. Caveolin-1 is a key component of membrane caveolae which plays an important role in cell transformation, cell migration, metastasis and angiogenesis. The mechanism of caveolin-1 and VEGF-C in lymphatic metastasis of non-small cell lung cancer (NSCLC) is still unclear. This study aimed to define the caveolin-1 and VEGF-C expression and lymph vessel density in NSCLC and look for correlations with clinicopathological features in NSCLC. Methods. Caveolin-1, VEGF-C, and D2-40 protein expression were assessed by immunohistochemistry in a tissuemicroarray constructed from70 NSCLCs and 12 normal lungs. Results. Caveolin-1 expression was detected in 31 of 70 (44.3%) NSCLCs, which was significantly lower than its expression in normal lungs (9 of 12, 75%; P = 0.049). Expression of VEGF-C was detected in 49 of 70 (70%) NSCLCs and 4 of 12 (33.3%) normal lungs (P = 0.022). Both caveolin-1 and VEGF-C expression were correlated with lymph node metastasis of NSCLC (P = 0.001; P = 0.028). Moreover, caveolin-1 expression was correlated with tumor stage, histological type, and differentiation grade (P = 0.012; P = 0.038; P = 0.002). VEGF-C expression was correlated only with histological type (P = 0.020). There was no correlation between intratumoral lymph vessel density and any clinicopathological parameters including lymph node status. Furthermore, there was no correlation between caveolin-1 expression, VEGF-C expression, and lymph vessel density. Conclusions. These findings indicated a reduction of caveolin-1 expression in NSCLC and suggested that caveolin-1 as well as VEGF-C might be involved in lymph node metastasis of NSCLC. The role of caveolin-1 in lymphaticmetastasis and intratumoral lymphangiogenesis in NSCLC needs further study. Free full text available at www. tumorionline.it.
KW - Caveolin-1
KW - Lymphangiogenesis
KW - Lymphatic metastasis
KW - NSCLC
KW - VEGF-C
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U2 - 10.1177/030089161009600516
DO - 10.1177/030089161009600516
M3 - Article
C2 - 21302621
AN - SCOPUS:78650453708
SN - 0300-8916
VL - 96
SP - 734
EP - 743
JO - Tumori
JF - Tumori
IS - 5
ER -