Abstract
Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in terminally differentiated cells. They are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking and signal transduction. The use of caveolin-1-deficient mice has provided many new insights into the roles of caveolae and caveolin-1 in the regulation of endothelial cell function. These novel findings suggest an important role for caveolin-1 in the pathogenesis of cancer, atherosclerosis, and vascular disease.
Original language | English (US) |
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Pages (from-to) | 1161-1168 |
Number of pages | 8 |
Journal | Arteriosclerosis, thrombosis, and vascular biology |
Volume | 23 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2003 |
Keywords
- Angiogenesis
- Atherosclerosis
- Caveolae
- Endothelial cells
- Transcytosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine