Abstract
Previous work has shown that optimal activation of CD4+ T cells requires co-stimulatory signals in addition to the primary signal provided by the antigen receptor. Recent work has demonstrated that CD28 is the primary co-stimulatory signal receptor for T cells, and 137 its natural ligand on antigen presenting cells. In the past year, it has become clear that the importance of CD28-mediated co-stimulatory signals extends to virtually all T-cell subsets. In addition, the existence of multiple ligands that are differentially expressed on antigen-presenting cells has been documented. The picture that is emerging is of a complex and dynamic interplay of co-stimulatory molecules on both the T cell and the antigen-presenting cell that serves to regulate activation. This offers novel approaches to the manipulation of immune responses in vivo.
Original language | English (US) |
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Pages (from-to) | 414-419 |
Number of pages | 6 |
Journal | Current Opinion in Immunology |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology