Abstract
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3',5'-monophosphate (cAMP)-specific phosphodiesterase-7 (PDET) was found to be a consequence of such costimulation. Increased PDE7 in T cells correlated with decreased cAMP, increased interleukin-2 expression, and increased proliferation. Selectively reducing PDE7 expression with a PDE7 antisense oligonucleotide inhibited T cell proliferation; inhibition was reversed by blocking the cAMP signaling pathways that operate through cAMP-dependent protein kinase (PKA) Thus, PDE7 induction and consequent suppression of PKA activity is required for T cell activation, and inhibition of PDE7 could be an approach to treating T cell- dependent disorders.
Original language | English (US) |
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Pages (from-to) | 848-849 |
Number of pages | 2 |
Journal | Science |
Volume | 283 |
Issue number | 5403 |
DOIs | |
State | Published - Feb 5 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- General