Abstract
CD30, a member of the tumour necrosis receptor superfamily, is physiologically expressed on a subpopulation of T helper cells in normal individuals but is also expressed on several malignant and virally transformed cells. Its ligand (CD30L) is a pleiotropic cellular transmembrane protein that can induce cell death in several CD30+ cell lines, CD30L expression has been reported on activated human peripheral blood T lymphocytes and macrophages but not on B cells. Here we show that the CD30L is expressed on resting normal and on malignant B cells in addition to both CD4+ and CD8+ subsets of activated T cells, making it the second tumour necrosis family member, in addition to the CD27 ligand, that can be expressed on both T and B cells. These findings raise the possibility that the CD30L has a role in B-cell/T-cell communication and that B and T cells are likely to be involved in the growth regulation of CD30+ tumours.
Original language | English (US) |
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Pages (from-to) | 569-571 |
Number of pages | 3 |
Journal | British Journal of Haematology |
Volume | 93 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |
Keywords
- CD30L
- CLL
- FACScan
- Lymphocytes
- RT-PCR
ASJC Scopus subject areas
- Hematology